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Long Non-Coding RNA XIST Promotes Wilms Tumor Progression Through the miR-194-5p/YAP Axis

Long Non-Coding RNA XIST Promotes Wilms Tumor Progression Through the miR-194-5p/YAP Axis

Posted on April 23, 2021 by Vawter

Though the lengthy non-coding RNA (lncRNA) X inactive-specific transcript (XIST) has been reported to have an anti-tumor impact in a number of malignant tumors, its function in Wilms tumor (WT) development has not been characterised. Thus, we investigated the underlying mechanism by which XIST regulates WT development. We carried out microarray evaluation and real-time quantitative PCR (RT-qPCR) to detect the expression ranges of XIST lncRNA, microRNA-194-5p (miR-194-5p), and YAP (yes-associated protein in Hippo pathway) in tumor and matched adjoining regular tissues and blood collected from 49 WT sufferers.

We additionally carried out bioinformatics analyses to determine differentially expressed genes. We measured the consequences of XIST overexpression and knockdown on cell proliferation, apoptosis, migration, and invasion, and its affiliation with the miR-194-5p/YAP pathway within the rhabdoid G401cell line utilizing circulate cytometry, transwell assays, immunohistochemistry, Western blot evaluation, and the twin luciferase reporter gene assay. Conversely, XIST downregulation inhibited WT cell proliferation, migration, and invasion and induced apoptosis.

We discovered that XIST lncRNA ranges had been elevated in blood and tissue samples of WT sufferers, and this upregulation was considerably correlated with TNM staging and shorter survival time. Notably, we discovered that XIST upregulation correlated with miR-194-5p downregulation and YAP upregulation in WT tissues, suggesting that XIST regulates the miR-194-5p/YAP pathway.  Our research revealed the oncogenic function of the lncRNA XIST in WT and demonstrated its function as a aggressive endogenous RNA that regulates the miR-194-5p/YAP pathway. Our research demonstrates XIST’s potential as a scientific prognostic biomarker and therapeutic goal for WT.
Differentially expressed genes had been recognized based mostly on three Gene Expression Omnibus (GEO) datasets. Primarily based on 1052 samples’ information from our cohort, GEO and The Most cancers Genome Atlas, we explored the connection of clinicopathological options and NEIL3 expression to find out scientific impact of NEIL3 in LUAD. Western blotting (22 pairs of tumor and regular tissues), Actual-time quantitative PCR (19 pairs of tumor and regular tissues), and immunohistochemical analyses (406-tumor tissues subjected to microarray) had been carried out. TIMER and ImmuCellAI analyzed relationship between NEIL3 expression and the abundance of tumor-infiltrating immune cells in LUAD. The co-expressed-gene prognostic signature was established based mostly on the Cox regression evaluation.

Transcriptomic profiling of three-dimensional cholangiocyte spheroids long run uncovered to repetitive Clonorchis sinensis excretory-secretory merchandise

Biliary tract an infection with the carcinogenic human liver fluke, Clonorchis sinensis, provokes power irritation, epithelial hyperplasia, periductal fibrosis, and even cholangiocarcinoma. Issues are proportional to the depth and period of the an infection. Along with mechanical irritation of the biliary epithelia from worms, their excretory-secretory merchandise (ESPs) trigger chemical irritation, which ends up in irritation, proliferation, and free radical era. A 3-dimensional in vitro cholangiocyte spheroid tradition mannequin was established, adopted by ESP remedy. This allowed us to look at the intrinsic pathological mechanisms of clonorchiasis by way of the imitation of extended and repetitive in vivo an infection.

Microarray and RNA-Seq evaluation revealed that ESP-treated cholangiocyte H69 spheroids displayed world modifications in gene expression in comparison with untreated spheroids. In ESP-treated H69 spheroids, 185 and 63 probes had been discovered to be considerably upregulated and downregulated, respectively, equivalent to 209 genes (p < 0.01, fold change > 2). RNA-Seq was carried out for the validation of the microarray outcomes, and the gene expression patterns in each transcriptome platforms had been properly matched for 209 important genes. Gene ontology evaluation demonstrated that differentially expressed genes had been primarily categorized into immune system processes, the extracellular area, and the extracellular matrix.

Among the many upregulated genes, 4 genes had been chosen for affirmation utilizing quantitative RT-PCR, leading to 100% related expression patterns in microarray and RNA-Seq. This research recognized 502 frequent differentially expressed genes and confirmed that NEIL3 was considerably overexpressed in LUAD samples (P < 0.001). Elevated NEIL3 expression was associated to superior stage, bigger tumor dimension and poor total survival (p < 0.001) in three LUAD cohorts. The proportions of pure T regulatory cells and induced T regulatory cells elevated within the excessive NEIL3 group, whereas these of B cells, Th17 cells and dendritic cells decreased. Gene set enrichment evaluation indicated that NEIL3 could activate cell cycle development and P53 signaling pathway, resulting in poor outcomes.

Long Non-Coding RNA XIST Promotes Wilms Tumor Progression Through the miR-194-5p/YAP Axis

Musk ketone induces apoptosis of gastric most cancers cells by way of downregulation of sorbin and SH3 area containing 2

Musk ketone exerts antiproliferative results on a number of varieties of most cancers, reminiscent of lung and breast most cancers. Nonetheless, the consequences and underlying mechanisms of motion of musk ketone in gastric most cancers (GC) are poorly understood. The current research aimed to research the consequences of musk ketone in GC cells. The current research indicated that musk ketone exerted important anticancer results on GC cells. The IC50 values of musk ketone had been 4.2 and 10.06 µM in AGS and HGC‑27 cells, respectively. Low dosage of musk ketone considerably suppressed the proliferation and colony formation of AGS and HGC‑27 cells. Cell cycle arrest and apoptosis had been induced by musk ketone.

Alpha-bungarotoxin, CF640r

9-00004 Biotium
  • EUR 592.80
  • EUR 193.20
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF488a

9-00005 Biotium
  • EUR 592.80
  • EUR 193.20
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin CF488a

9-00005 Biotium
  • EUR 592.80
  • EUR 193.20
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF568

9-00006 Biotium
  • EUR 592.80
  • EUR 193.20
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin, CF568

9-00006 Biotium
  • EUR 592.80
  • EUR 193.20
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF594

9-00007 Biotium
  • EUR 592.80
  • EUR 193.20
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin CF594

9-00007 Biotium
  • EUR 592.80
  • EUR 193.20
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF633

9-00009 Biotium
  • EUR 592.80
  • EUR 193.20
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin, CF633

9-00009 Biotium
  • EUR 592.80
  • EUR 193.20
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin

00010-1 Biotium 1MG
EUR 201.6
Description: Minimum order quantity: 1 unit of 1MG

Fluorescein-Alpha-bungarotoxin

00011 Biotium 500uG
EUR 440.4
Description: Minimum order quantity: 1 unit of 500uG

Tetramethylrhodamine-Alpha-bungarotoxin

00012 Biotium 500uG
EUR 459.6
Description: Minimum order quantity: 1 unit of 500uG

Fluorescein-alpha-bungarotoxin: (10x50ug)

00013 Biotium 10ST
EUR 500.4
Description: Minimum order quantity: 1 unit of 10ST

Tetramethylrhodamine-alpha-bungarotoxin: (10x50ug)

00014 Biotium 10ST
EUR 559.2
Description: Minimum order quantity: 1 unit of 10ST

Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (500ug)

00015 Biotium 500uG
EUR 559.2
Description: Minimum order quantity: 1 unit of 500uG

Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (10x50ug)

00016 Biotium 10ST
EUR 627.6
Description: Minimum order quantity: 1 unit of 10ST

Biotin-xx-a-bungarotoxin

00017 Biotium 500uG
EUR 519.6
Description: Minimum order quantity: 1 unit of 500uG

Alpha-Bungarotoxin, CF555 conjugate

9-00018 Biotium
  • EUR 592.80
  • EUR 193.20
  • 500uG
  • 100ug
Description: Minimum order quantity: 1 unit of 500uG

Alpha-Bungarotoxin, CF555 conjugate

9-00018 Biotium
  • EUR 592.80
  • EUR 193.20
  • 500uG
  • 100ug
Description: Minimum order quantity: 1 unit of 100ug

Biotin-cAMP, diisopropylethylammonium salt:

00020 Biotium 1MG
EUR 376.8
Description: Minimum order quantity: 1 unit of 1MG

Biotin-cAMP, diisopropylethylammonium salt: (20x50ug)

00020-1 Biotium 20ST
EUR 501.6
Description: Minimum order quantity: 1 unit of 20ST

Biotin-cGMP, diisopropylethylammonium salt:

00021 Biotium 1MG
EUR 412.8
Description: Minimum order quantity: 1 unit of 1MG

Biotin-cGMP, diisopropylethylammonium salt: (20x50ug)

00021-1 Biotium 20ST
EUR 537.6
Description: Minimum order quantity: 1 unit of 20ST

Cyanine 644-cAMP:

00022 Biotium 1MG
EUR 589.2
Description: Minimum order quantity: 1 unit of 1MG

Cyanine 644-cAMP: (20x50ug)

00022-1 Biotium 20ST
EUR 750
Description: Minimum order quantity: 1 unit of 20ST

Fluorescein Methotrexate, triammonium salt:

00023 Biotium 1MG
EUR 337.2
Description: Minimum order quantity: 1 unit of 1MG

Staurosporine

00025 Biotium 100uG
EUR 166.8
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF543

00026 Biotium 500uG
EUR 592.8
Description: Minimum order quantity: 1 unit of 500uG

Rhodamine phalloidin 300u

00027 Biotium 300
EUR 414
Description: Minimum order quantity: 1 unit of 300

Biotin-xx-phalloidin

00028 Biotium 100U
EUR 513.6
Description: Minimum order quantity: 1 unit of 100U

Fluorescein-phalloidin

00030 Biotium 300U
EUR 414
Description: Minimum order quantity: 1 unit of 300U

Rhodamine 110 phalloidin

00032 Biotium 300ST
EUR 414
Description: Minimum order quantity: 1 unit of 300ST

Sulforhodamine 101 (Texas-Red) Phalloidin

00033 Biotium 300EU
EUR 414
Description: Minimum order quantity: 1 unit of 300EU

Phalloidin, CF405M

00034 Biotium 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF405M

00034-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

CF488A-cAMP

00036 Biotium 100ug
EUR 206.4
Description: Minimum order quantity: 1 unit of 100ug

CF640R-cAMP

00037 Biotium 100ug
EUR 206.4
Description: Minimum order quantity: 1 unit of 100ug

Phalloidin, CF555

00040 Biotium 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF555

00040-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF647

00041 Biotium 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF647

00041-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF488A

00042 Biotium 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF488A

00042-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF543

00043 Biotium 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF543

00043-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF568

00044 Biotium 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF568

00044-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF594

00045 Biotium 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF594

00045-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF633

00046 Biotium 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF633

00046-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF660R

00047 Biotium 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF660R

00047-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF680R

00048 Biotium 300U
EUR 559.2
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF680R

00048-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF350

00049 Biotium 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF350

00049-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF640R

00050 Biotium 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF640R

00050-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF532

00051 Biotium 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF532

00051-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF660C

00052 Biotium 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF660C

00052-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF680

00053 Biotium 300U
EUR 559.2
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF680

00053-T Biotium 50U
EUR 176.4
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF430

00054 Biotium 300U
EUR 538.8
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF430

00054-T Biotium 50U
EUR 166.8
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF440

00055 Biotium 300U
EUR 538.8
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF440

00055-T Biotium 50U
EUR 166.8
Description: Minimum order quantity: 1 unit of 50U

Cholera Toxin Subunit B, CF488A conjugate

00070 Biotium 100ug
EUR 313.2
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF568 conjugate

00071 Biotium 100ug
EUR 313.2
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF594 conjugate

00072 Biotium 100ug
EUR 313.2
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF640R conjugate

00073 Biotium 100ug
EUR 316.8
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF532 conjugate

00074 Biotium 100ug
EUR 316.8
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF543 conjugate

00075 Biotium 100ug
EUR 316.8
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF620R conjugate

00076 Biotium 100ug
EUR 316.8
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF633 conjugate

00077 Biotium 100ug
EUR 316.8
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF660R conjugate

00078 Biotium 100ug
EUR 316.8
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF680R conjugate

00079 Biotium 100ug
EUR 338.4
Description: Minimum order quantity: 1 unit of 100ug

Human Transferrin, CF488A conjugate

00081 Biotium 1mg
EUR 178.8
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF543 conjugate

00082 Biotium 1mg
EUR 178.8
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF568 conjugate

00083 Biotium 1mg
EUR 178.8
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF594 conjugate

00084 Biotium 1mg
EUR 178.8
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF640R conjugate

00085 Biotium 1mg
EUR 178.8
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF680R conjugate

00086 Biotium 1mg
EUR 178.8
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF750 conjugate

00087 Biotium 1mg
EUR 186
Description: Minimum order quantity: 1 unit of 1mg

HIV-1 tat recombinant antigen

00110-V-01mg Virogen 0,1 mg
EUR 321
Description: HIV-1 tat recombinant antigen full length 15 kDa

HIV-1 tat recombinant antigen

00110-V-1000ug Virogen 1000 ug
EUR 1539
Description: HIV-1 tat recombinant antigen full length 15 kDa

HIV-1 GAG P24 Recombinant Antigen

00111-V-01mg Virogen 0,1 mg
EUR 321
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

HIV-1 GAG P24 Recombinant Antigen

00111-V-1000ug Virogen 1000 ug
EUR 1539
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

HIV-1 nef recombinant antigen

00112-V-01mg Virogen 0,1 mg
EUR 321
Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa

HIV-1 nef recombinant antigen

00112-V-1000ug Virogen 1000 ug
EUR 1539
Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa

HIV-1 env gp41 recombinant antigen

00113-V-01mg Virogen 0,1 mg
EUR 321
Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa

HIV-1 env gp41 recombinant antigen

00113-V-1000ug Virogen 1000 ug
EUR 1539
Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa

HIV-2 GP 36 Recombinant Antigen

00114-V-01mg Virogen 0,1 mg
EUR 321
Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa

HIV-2 GP 36 Recombinant Antigen

00114-V-1000ug Virogen 1000 ug
EUR 1539
Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa

HCV core recombinant antigen

00115-V-01mg Virogen 0,1 mg
EUR 321
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa

HCV core recombinant antigen

00115-V-1000ug Virogen 1000 ug
EUR 1539
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa

HCV core recombinant antigen, Biotin conjugate

00115-V-B-01mg Virogen 0,1 mg
EUR 321
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate.

HCV core recombinant antigen, Biotin conjugate

00115-V-B-1000ug Virogen 1000 ug
EUR 1539
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate.

HCV core recombinant antigen, FITC conjugate

00115-V-F-01mg Virogen 0,1 mg
EUR 321
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate.

HCV core recombinant antigen, FITC conjugate

00115-V-F-1000ug Virogen 1000 ug
EUR 1539
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate.

HCV core recombinant antigen, Rhodamine

00115-V-R-01mg Virogen 0,1 mg
EUR 321
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate.

HCV core recombinant antigen, Rhodamine

00115-V-R-1000ug Virogen 1000 ug
EUR 1539
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate.

HCV NS4 recombinant antigen NS4a+b

00116-V-01mg Virogen 0,1 mg
EUR 321
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa.

HCV NS4 recombinant antigen NS4a+b

00116-V-1000ug Virogen 1000 ug
EUR 1539
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa.

HCV NS4 recombinant antigen NS4a+b, Biotin

00116-V-B-01mg Virogen 0,1 mg
EUR 321
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Biotin conjugate.

HCV NS4 recombinant antigen NS4a+b, Biotin

00116-V-B-1000ug Virogen 1000 ug
EUR 1539
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Biotin conjugate.

HCV NS4 recombinant antigen NS4a+b, FITC

00116-V-F-01mg Virogen 0,1 mg
EUR 321
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Fluorescein conjugate.

HCV NS4 recombinant antigen NS4a+b, FITC

00116-V-F-1000ug Virogen 1000 ug
EUR 1539
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Fluorescein conjugate.

HCV NS4 recombinant antigen NS4a+b, Rhodamine

00116-V-R-01mg Virogen 0,1 mg
EUR 321
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Rhodamine conjugate.

HCV NS4 recombinant antigen NS4a+b, Rhodamine

00116-V-R-1000ug Virogen 1000 ug
EUR 1539
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Rhodamine conjugate.

HCV NS3 recombinant antigen

00117-V-01mg Virogen 0,1 mg
EUR 321
Description: HCV NS3 recombinant antigen a.a 1400 to a.a 1643 of HCV polyprotein 22 kDa

HCV NS3 recombinant antigen

00117-V-1000ug Virogen 1000 ug
EUR 1539
Description: HCV NS3 recombinant antigen a.a 1400 to a.a 1643 of HCV polyprotein 22 kDa

HBV core recombinant antigen

00120-V-01mg Virogen 0,1 mg
EUR 321
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 183 of HBV core antigen 18 kDa

HBV core recombinant antigen

00120-V-1000ug Virogen 1000 ug
EUR 1539
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 183 of HBV core antigen 18 kDa

HBV core recombinant antigen, Delta

00121-V-01mg Virogen 0,1 mg
EUR 321
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 144 of HBV core antigen 16 kDa

HBV core recombinant antigen, Delta

00121-V-1000ug Virogen 1000 ug
EUR 1539
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 144 of HBV core antigen 16 kDa

HBV surface recombinant antigen HBsAg

00122-V-01mg Virogen 0,1 mg
EUR 321
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant

HBV surface recombinant antigen HBsAg

00122-V-1000ug Virogen 1000 ug
EUR 1539
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant

HBV surface recombinant antigen HBsAg antigen

00123-V-01mg Virogen 0,1 mg
EUR 321
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant High purity

HBV surface recombinant antigen HBsAg antigen

00123-V-1000ug Virogen 1000 ug
EUR 1539
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant High purity
×

Moreover, microarray information indicated that musk ketone remedy led to downregulation of varied genes, together with sorbin and SH3 area containing 2 (SORBS2). Reverse transcription‑quantitative PCR and immunoblotting outcomes indicated that musk ketone repressed mRNA and protein expression ranges of SORBS2. It was additionally proven that knockdown of SORBS2 inhibited the proliferation and colony formation of HGC‑27 cells. The antiproliferative results of musk ketone had been decreased in HGC‑27 cells with SORBS2 silencing. In abstract, the current research indicated that musk ketone suppressed the proliferation and progress of GC partly by downregulating SORBS2 expression.

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  • Blog
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Recent Posts

  • PolymorphPrep
  • Capilia TB-Neo
  • Rabies Ag Test Kit
  • Bakkenolide‑IIIa ameliorates lipopolysaccharide‑induced inflammatory injury in human umbilical vein endothelial cells by upregulating LINC00294
  • Human Inflammatory Neutrophils Express Genes Encoding Peptidase Inhibitors: Production of Elafin Mediated by NF-κB and CCAAT/Enhancer-Binding Protein β
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