Though the lengthy non-coding RNA (lncRNA) X inactive-specific transcript (XIST) has been reported to have an anti-tumor impact in a number of malignant tumors, its function in Wilms tumor (WT) development has not been characterised. Thus, we investigated the underlying mechanism by which XIST regulates WT development. We carried out microarray evaluation and real-time quantitative PCR (RT-qPCR) to detect the expression ranges of XIST lncRNA, microRNA-194-5p (miR-194-5p), and YAP (yes-associated protein in Hippo pathway) in tumor and matched adjoining regular tissues and blood collected from 49 WT sufferers.
We additionally carried out bioinformatics analyses to determine differentially expressed genes. We measured the consequences of XIST overexpression and knockdown on cell proliferation, apoptosis, migration, and invasion, and its affiliation with the miR-194-5p/YAP pathway within the rhabdoid G401cell line utilizing circulate cytometry, transwell assays, immunohistochemistry, Western blot evaluation, and the twin luciferase reporter gene assay. Conversely, XIST downregulation inhibited WT cell proliferation, migration, and invasion and induced apoptosis.
We discovered that XIST lncRNA ranges had been elevated in blood and tissue samples of WT sufferers, and this upregulation was considerably correlated with TNM staging and shorter survival time. Notably, we discovered that XIST upregulation correlated with miR-194-5p downregulation and YAP upregulation in WT tissues, suggesting that XIST regulates the miR-194-5p/YAP pathway. Our research revealed the oncogenic function of the lncRNA XIST in WT and demonstrated its function as a aggressive endogenous RNA that regulates the miR-194-5p/YAP pathway. Our research demonstrates XIST’s potential as a scientific prognostic biomarker and therapeutic goal for WT.
Differentially expressed genes had been recognized based mostly on three Gene Expression Omnibus (GEO) datasets. Primarily based on 1052 samples’ information from our cohort, GEO and The Most cancers Genome Atlas, we explored the connection of clinicopathological options and NEIL3 expression to find out scientific impact of NEIL3 in LUAD. Western blotting (22 pairs of tumor and regular tissues), Actual-time quantitative PCR (19 pairs of tumor and regular tissues), and immunohistochemical analyses (406-tumor tissues subjected to microarray) had been carried out. TIMER and ImmuCellAI analyzed relationship between NEIL3 expression and the abundance of tumor-infiltrating immune cells in LUAD. The co-expressed-gene prognostic signature was established based mostly on the Cox regression evaluation.
Transcriptomic profiling of three-dimensional cholangiocyte spheroids long run uncovered to repetitive Clonorchis sinensis excretory-secretory merchandise
Biliary tract an infection with the carcinogenic human liver fluke, Clonorchis sinensis, provokes power irritation, epithelial hyperplasia, periductal fibrosis, and even cholangiocarcinoma. Issues are proportional to the depth and period of the an infection. Along with mechanical irritation of the biliary epithelia from worms, their excretory-secretory merchandise (ESPs) trigger chemical irritation, which ends up in irritation, proliferation, and free radical era. A 3-dimensional in vitro cholangiocyte spheroid tradition mannequin was established, adopted by ESP remedy. This allowed us to look at the intrinsic pathological mechanisms of clonorchiasis by way of the imitation of extended and repetitive in vivo an infection.
Microarray and RNA-Seq evaluation revealed that ESP-treated cholangiocyte H69 spheroids displayed world modifications in gene expression in comparison with untreated spheroids. In ESP-treated H69 spheroids, 185 and 63 probes had been discovered to be considerably upregulated and downregulated, respectively, equivalent to 209 genes (p < 0.01, fold change > 2). RNA-Seq was carried out for the validation of the microarray outcomes, and the gene expression patterns in each transcriptome platforms had been properly matched for 209 important genes. Gene ontology evaluation demonstrated that differentially expressed genes had been primarily categorized into immune system processes, the extracellular area, and the extracellular matrix.
Among the many upregulated genes, 4 genes had been chosen for affirmation utilizing quantitative RT-PCR, leading to 100% related expression patterns in microarray and RNA-Seq. This research recognized 502 frequent differentially expressed genes and confirmed that NEIL3 was considerably overexpressed in LUAD samples (P < 0.001). Elevated NEIL3 expression was associated to superior stage, bigger tumor dimension and poor total survival (p < 0.001) in three LUAD cohorts. The proportions of pure T regulatory cells and induced T regulatory cells elevated within the excessive NEIL3 group, whereas these of B cells, Th17 cells and dendritic cells decreased. Gene set enrichment evaluation indicated that NEIL3 could activate cell cycle development and P53 signaling pathway, resulting in poor outcomes.
Musk ketone induces apoptosis of gastric most cancers cells by way of downregulation of sorbin and SH3 area containing 2
Musk ketone exerts antiproliferative results on a number of varieties of most cancers, reminiscent of lung and breast most cancers. Nonetheless, the consequences and underlying mechanisms of motion of musk ketone in gastric most cancers (GC) are poorly understood. The current research aimed to research the consequences of musk ketone in GC cells. The current research indicated that musk ketone exerted important anticancer results on GC cells. The IC50 values of musk ketone had been 4.2 and 10.06 µM in AGS and HGC‑27 cells, respectively. Low dosage of musk ketone considerably suppressed the proliferation and colony formation of AGS and HGC‑27 cells. Cell cycle arrest and apoptosis had been induced by musk ketone.
Alpha-bungarotoxin, CF640r |
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| 9-00004 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
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Alpha-bungarotoxin, CF488a |
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| 9-00005 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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Alpha-bungarotoxin CF488a |
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| 9-00005 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
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Alpha-bungarotoxin, CF568 |
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| 9-00006 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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Alpha-bungarotoxin, CF568 |
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| 9-00006 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
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Alpha-bungarotoxin, CF594 |
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| 9-00007 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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Alpha-bungarotoxin CF594 |
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| 9-00007 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
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Alpha-bungarotoxin, CF633 |
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| 9-00009 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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Alpha-bungarotoxin, CF633 |
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| 9-00009 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
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Alpha-bungarotoxin |
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| 00010-1 | Biotium | 1MG | EUR 201.6 |
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Description: Minimum order quantity: 1 unit of 1MG |
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Fluorescein-Alpha-bungarotoxin |
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| 00011 | Biotium | 500uG | EUR 440.4 |
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Description: Minimum order quantity: 1 unit of 500uG |
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Tetramethylrhodamine-Alpha-bungarotoxin |
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| 00012 | Biotium | 500uG | EUR 459.6 |
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Description: Minimum order quantity: 1 unit of 500uG |
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Fluorescein-alpha-bungarotoxin: (10x50ug) |
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| 00013 | Biotium | 10ST | EUR 500.4 |
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Description: Minimum order quantity: 1 unit of 10ST |
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Tetramethylrhodamine-alpha-bungarotoxin: (10x50ug) |
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| 00014 | Biotium | 10ST | EUR 559.2 |
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Description: Minimum order quantity: 1 unit of 10ST |
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Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (500ug) |
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| 00015 | Biotium | 500uG | EUR 559.2 |
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Description: Minimum order quantity: 1 unit of 500uG |
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Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (10x50ug) |
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| 00016 | Biotium | 10ST | EUR 627.6 |
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Description: Minimum order quantity: 1 unit of 10ST |
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Biotin-xx-a-bungarotoxin |
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| 00017 | Biotium | 500uG | EUR 519.6 |
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Description: Minimum order quantity: 1 unit of 500uG |
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Alpha-Bungarotoxin, CF555 conjugate |
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| 9-00018 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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Alpha-Bungarotoxin, CF555 conjugate |
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| 9-00018 | Biotium |
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Description: Minimum order quantity: 1 unit of 100ug |
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Biotin-cAMP, diisopropylethylammonium salt: |
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| 00020 | Biotium | 1MG | EUR 376.8 |
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Description: Minimum order quantity: 1 unit of 1MG |
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Biotin-cAMP, diisopropylethylammonium salt: (20x50ug) |
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| 00020-1 | Biotium | 20ST | EUR 501.6 |
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Description: Minimum order quantity: 1 unit of 20ST |
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Biotin-cGMP, diisopropylethylammonium salt: |
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| 00021 | Biotium | 1MG | EUR 412.8 |
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Description: Minimum order quantity: 1 unit of 1MG |
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Biotin-cGMP, diisopropylethylammonium salt: (20x50ug) |
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| 00021-1 | Biotium | 20ST | EUR 537.6 |
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Description: Minimum order quantity: 1 unit of 20ST |
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Cyanine 644-cAMP: |
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| 00022 | Biotium | 1MG | EUR 589.2 |
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Description: Minimum order quantity: 1 unit of 1MG |
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Cyanine 644-cAMP: (20x50ug) |
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| 00022-1 | Biotium | 20ST | EUR 750 |
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Description: Minimum order quantity: 1 unit of 20ST |
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Fluorescein Methotrexate, triammonium salt: |
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| 00023 | Biotium | 1MG | EUR 337.2 |
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Description: Minimum order quantity: 1 unit of 1MG |
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Staurosporine |
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| 00025 | Biotium | 100uG | EUR 166.8 |
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Description: Minimum order quantity: 1 unit of 100uG |
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Alpha-bungarotoxin, CF543 |
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| 00026 | Biotium | 500uG | EUR 592.8 |
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Description: Minimum order quantity: 1 unit of 500uG |
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Rhodamine phalloidin 300u |
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| 00027 | Biotium | 300 | EUR 414 |
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Description: Minimum order quantity: 1 unit of 300 |
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Biotin-xx-phalloidin |
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| 00028 | Biotium | 100U | EUR 513.6 |
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Description: Minimum order quantity: 1 unit of 100U |
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Fluorescein-phalloidin |
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| 00030 | Biotium | 300U | EUR 414 |
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Description: Minimum order quantity: 1 unit of 300U |
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Rhodamine 110 phalloidin |
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| 00032 | Biotium | 300ST | EUR 414 |
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Description: Minimum order quantity: 1 unit of 300ST |
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Sulforhodamine 101 (Texas-Red) Phalloidin |
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| 00033 | Biotium | 300EU | EUR 414 |
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Description: Minimum order quantity: 1 unit of 300EU |
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Phalloidin, CF405M |
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| 00034 | Biotium | 300U | EUR 530.4 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF405M |
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| 00034-T | Biotium | 50U | EUR 159.6 |
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Description: Minimum order quantity: 1 unit of 50U |
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CF488A-cAMP |
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| 00036 | Biotium | 100ug | EUR 206.4 |
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Description: Minimum order quantity: 1 unit of 100ug |
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CF640R-cAMP |
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| 00037 | Biotium | 100ug | EUR 206.4 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Phalloidin, CF555 |
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| 00040 | Biotium | 300U | EUR 530.4 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF555 |
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| 00040-T | Biotium | 50U | EUR 159.6 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF647 |
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| 00041 | Biotium | 300U | EUR 530.4 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF647 |
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| 00041-T | Biotium | 50U | EUR 159.6 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF488A |
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| 00042 | Biotium | 300U | EUR 530.4 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF488A |
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| 00042-T | Biotium | 50U | EUR 159.6 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF543 |
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| 00043 | Biotium | 300U | EUR 530.4 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF543 |
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| 00043-T | Biotium | 50U | EUR 159.6 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF568 |
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| 00044 | Biotium | 300U | EUR 530.4 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF568 |
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| 00044-T | Biotium | 50U | EUR 159.6 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF594 |
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| 00045 | Biotium | 300U | EUR 530.4 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF594 |
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| 00045-T | Biotium | 50U | EUR 159.6 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF633 |
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| 00046 | Biotium | 300U | EUR 530.4 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF633 |
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| 00046-T | Biotium | 50U | EUR 159.6 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF660R |
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| 00047 | Biotium | 300U | EUR 530.4 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF660R |
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| 00047-T | Biotium | 50U | EUR 159.6 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF680R |
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| 00048 | Biotium | 300U | EUR 559.2 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF680R |
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| 00048-T | Biotium | 50U | EUR 159.6 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF350 |
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| 00049 | Biotium | 300U | EUR 530.4 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF350 |
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| 00049-T | Biotium | 50U | EUR 159.6 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF640R |
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| 00050 | Biotium | 300U | EUR 530.4 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF640R |
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| 00050-T | Biotium | 50U | EUR 159.6 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF532 |
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| 00051 | Biotium | 300U | EUR 530.4 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF532 |
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| 00051-T | Biotium | 50U | EUR 159.6 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF660C |
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| 00052 | Biotium | 300U | EUR 530.4 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF660C |
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| 00052-T | Biotium | 50U | EUR 159.6 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF680 |
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| 00053 | Biotium | 300U | EUR 559.2 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF680 |
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| 00053-T | Biotium | 50U | EUR 176.4 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF430 |
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| 00054 | Biotium | 300U | EUR 538.8 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF430 |
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| 00054-T | Biotium | 50U | EUR 166.8 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF440 |
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| 00055 | Biotium | 300U | EUR 538.8 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF440 |
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| 00055-T | Biotium | 50U | EUR 166.8 |
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Description: Minimum order quantity: 1 unit of 50U |
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Cholera Toxin Subunit B, CF488A conjugate |
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| 00070 | Biotium | 100ug | EUR 313.2 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Cholera Toxin Subunit B, CF568 conjugate |
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| 00071 | Biotium | 100ug | EUR 313.2 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Cholera Toxin Subunit B, CF594 conjugate |
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| 00072 | Biotium | 100ug | EUR 313.2 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Cholera Toxin Subunit B, CF640R conjugate |
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| 00073 | Biotium | 100ug | EUR 316.8 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Cholera Toxin Subunit B, CF532 conjugate |
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| 00074 | Biotium | 100ug | EUR 316.8 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Cholera Toxin Subunit B, CF543 conjugate |
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| 00075 | Biotium | 100ug | EUR 316.8 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Cholera Toxin Subunit B, CF620R conjugate |
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| 00076 | Biotium | 100ug | EUR 316.8 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Cholera Toxin Subunit B, CF633 conjugate |
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| 00077 | Biotium | 100ug | EUR 316.8 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Cholera Toxin Subunit B, CF660R conjugate |
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| 00078 | Biotium | 100ug | EUR 316.8 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Cholera Toxin Subunit B, CF680R conjugate |
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| 00079 | Biotium | 100ug | EUR 338.4 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Human Transferrin, CF488A conjugate |
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| 00081 | Biotium | 1mg | EUR 178.8 |
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Description: Minimum order quantity: 1 unit of 1mg |
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Human Transferrin, CF543 conjugate |
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| 00082 | Biotium | 1mg | EUR 178.8 |
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Description: Minimum order quantity: 1 unit of 1mg |
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Human Transferrin, CF568 conjugate |
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| 00083 | Biotium | 1mg | EUR 178.8 |
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Description: Minimum order quantity: 1 unit of 1mg |
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Human Transferrin, CF594 conjugate |
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| 00084 | Biotium | 1mg | EUR 178.8 |
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Description: Minimum order quantity: 1 unit of 1mg |
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Human Transferrin, CF640R conjugate |
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| 00085 | Biotium | 1mg | EUR 178.8 |
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Description: Minimum order quantity: 1 unit of 1mg |
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Human Transferrin, CF680R conjugate |
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| 00086 | Biotium | 1mg | EUR 178.8 |
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Description: Minimum order quantity: 1 unit of 1mg |
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Human Transferrin, CF750 conjugate |
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| 00087 | Biotium | 1mg | EUR 186 |
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Description: Minimum order quantity: 1 unit of 1mg |
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HIV-1 tat recombinant antigen |
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| 00110-V-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: HIV-1 tat recombinant antigen full length 15 kDa |
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HIV-1 tat recombinant antigen |
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| 00110-V-1000ug | Virogen | 1000 ug | EUR 1539 |
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Description: HIV-1 tat recombinant antigen full length 15 kDa |
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HIV-1 GAG P24 Recombinant Antigen |
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| 00111-V-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa |
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HIV-1 GAG P24 Recombinant Antigen |
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| 00111-V-1000ug | Virogen | 1000 ug | EUR 1539 |
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Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa |
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HIV-1 nef recombinant antigen |
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| 00112-V-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa |
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HIV-1 nef recombinant antigen |
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| 00112-V-1000ug | Virogen | 1000 ug | EUR 1539 |
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Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa |
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HIV-1 env gp41 recombinant antigen |
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| 00113-V-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa |
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HIV-1 env gp41 recombinant antigen |
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| 00113-V-1000ug | Virogen | 1000 ug | EUR 1539 |
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Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa |
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HIV-2 GP 36 Recombinant Antigen |
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| 00114-V-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa |
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HIV-2 GP 36 Recombinant Antigen |
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| 00114-V-1000ug | Virogen | 1000 ug | EUR 1539 |
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Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa |
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HCV core recombinant antigen |
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| 00115-V-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa |
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HCV core recombinant antigen |
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| 00115-V-1000ug | Virogen | 1000 ug | EUR 1539 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa |
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HCV core recombinant antigen, Biotin conjugate |
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| 00115-V-B-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate. |
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HCV core recombinant antigen, Biotin conjugate |
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| 00115-V-B-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate. |
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HCV core recombinant antigen, FITC conjugate |
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| 00115-V-F-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate. |
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HCV core recombinant antigen, FITC conjugate |
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| 00115-V-F-1000ug | Virogen | 1000 ug | EUR 1539 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate. |
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HCV core recombinant antigen, Rhodamine |
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| 00115-V-R-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate. |
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HCV core recombinant antigen, Rhodamine |
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| 00115-V-R-1000ug | Virogen | 1000 ug | EUR 1539 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate. |
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HCV NS4 recombinant antigen NS4a+b |
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| 00116-V-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. |
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HCV NS4 recombinant antigen NS4a+b |
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| 00116-V-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. |
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HCV NS4 recombinant antigen NS4a+b, Biotin |
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| 00116-V-B-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Biotin conjugate. |
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HCV NS4 recombinant antigen NS4a+b, Biotin |
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| 00116-V-B-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Biotin conjugate. |
|||
HCV NS4 recombinant antigen NS4a+b, FITC |
|||
| 00116-V-F-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Fluorescein conjugate. |
|||
HCV NS4 recombinant antigen NS4a+b, FITC |
|||
| 00116-V-F-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Fluorescein conjugate. |
|||
HCV NS4 recombinant antigen NS4a+b, Rhodamine |
|||
| 00116-V-R-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Rhodamine conjugate. |
|||
HCV NS4 recombinant antigen NS4a+b, Rhodamine |
|||
| 00116-V-R-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Rhodamine conjugate. |
|||
HCV NS3 recombinant antigen |
|||
| 00117-V-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HCV NS3 recombinant antigen a.a 1400 to a.a 1643 of HCV polyprotein 22 kDa |
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HCV NS3 recombinant antigen |
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| 00117-V-1000ug | Virogen | 1000 ug | EUR 1539 |
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Description: HCV NS3 recombinant antigen a.a 1400 to a.a 1643 of HCV polyprotein 22 kDa |
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HBV core recombinant antigen |
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| 00120-V-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 183 of HBV core antigen 18 kDa |
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HBV core recombinant antigen |
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| 00120-V-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 183 of HBV core antigen 18 kDa |
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HBV core recombinant antigen, Delta |
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| 00121-V-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 144 of HBV core antigen 16 kDa |
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HBV core recombinant antigen, Delta |
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| 00121-V-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 144 of HBV core antigen 16 kDa |
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HBV surface recombinant antigen HBsAg |
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| 00122-V-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant |
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HBV surface recombinant antigen HBsAg |
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| 00122-V-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant |
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HBV surface recombinant antigen HBsAg antigen |
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| 00123-V-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant High purity |
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HBV surface recombinant antigen HBsAg antigen |
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| 00123-V-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant High purity |
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Moreover, microarray information indicated that musk ketone remedy led to downregulation of varied genes, together with sorbin and SH3 area containing 2 (SORBS2). Reverse transcription‑quantitative PCR and immunoblotting outcomes indicated that musk ketone repressed mRNA and protein expression ranges of SORBS2. It was additionally proven that knockdown of SORBS2 inhibited the proliferation and colony formation of HGC‑27 cells. The antiproliferative results of musk ketone had been decreased in HGC‑27 cells with SORBS2 silencing. In abstract, the current research indicated that musk ketone suppressed the proliferation and progress of GC partly by downregulating SORBS2 expression.