Though the lengthy non-coding RNA (lncRNA) X inactive-specific transcript (XIST) has been reported to have an anti-tumor impact in a number of malignant tumors, its function in Wilms tumor (WT) development has not been characterised. Thus, we investigated the underlying mechanism by which XIST regulates WT development. We carried out microarray evaluation and real-time quantitative PCR (RT-qPCR) to detect the expression ranges of XIST lncRNA, microRNA-194-5p (miR-194-5p), and YAP (yes-associated protein in Hippo pathway) in tumor and matched adjoining regular tissues and blood collected from 49 WT sufferers.
We additionally carried out bioinformatics analyses to determine differentially expressed genes. We measured the consequences of XIST overexpression and knockdown on cell proliferation, apoptosis, migration, and invasion, and its affiliation with the miR-194-5p/YAP pathway within the rhabdoid G401cell line utilizing circulate cytometry, transwell assays, immunohistochemistry, Western blot evaluation, and the twin luciferase reporter gene assay. Conversely, XIST downregulation inhibited WT cell proliferation, migration, and invasion and induced apoptosis.
We discovered that XIST lncRNA ranges had been elevated in blood and tissue samples of WT sufferers, and this upregulation was considerably correlated with TNM staging and shorter survival time. Notably, we discovered that XIST upregulation correlated with miR-194-5p downregulation and YAP upregulation in WT tissues, suggesting that XIST regulates the miR-194-5p/YAP pathway. Our research revealed the oncogenic function of the lncRNA XIST in WT and demonstrated its function as a aggressive endogenous RNA that regulates the miR-194-5p/YAP pathway. Our research demonstrates XIST’s potential as a scientific prognostic biomarker and therapeutic goal for WT.
Differentially expressed genes had been recognized based mostly on three Gene Expression Omnibus (GEO) datasets. Primarily based on 1052 samples’ information from our cohort, GEO and The Most cancers Genome Atlas, we explored the connection of clinicopathological options and NEIL3 expression to find out scientific impact of NEIL3 in LUAD. Western blotting (22 pairs of tumor and regular tissues), Actual-time quantitative PCR (19 pairs of tumor and regular tissues), and immunohistochemical analyses (406-tumor tissues subjected to microarray) had been carried out. TIMER and ImmuCellAI analyzed relationship between NEIL3 expression and the abundance of tumor-infiltrating immune cells in LUAD. The co-expressed-gene prognostic signature was established based mostly on the Cox regression evaluation.
Transcriptomic profiling of three-dimensional cholangiocyte spheroids long run uncovered to repetitive Clonorchis sinensis excretory-secretory merchandise
Biliary tract an infection with the carcinogenic human liver fluke, Clonorchis sinensis, provokes power irritation, epithelial hyperplasia, periductal fibrosis, and even cholangiocarcinoma. Issues are proportional to the depth and period of the an infection. Along with mechanical irritation of the biliary epithelia from worms, their excretory-secretory merchandise (ESPs) trigger chemical irritation, which ends up in irritation, proliferation, and free radical era. A 3-dimensional in vitro cholangiocyte spheroid tradition mannequin was established, adopted by ESP remedy. This allowed us to look at the intrinsic pathological mechanisms of clonorchiasis by way of the imitation of extended and repetitive in vivo an infection.
Microarray and RNA-Seq evaluation revealed that ESP-treated cholangiocyte H69 spheroids displayed world modifications in gene expression in comparison with untreated spheroids. In ESP-treated H69 spheroids, 185 and 63 probes had been discovered to be considerably upregulated and downregulated, respectively, equivalent to 209 genes (p < 0.01, fold change > 2). RNA-Seq was carried out for the validation of the microarray outcomes, and the gene expression patterns in each transcriptome platforms had been properly matched for 209 important genes. Gene ontology evaluation demonstrated that differentially expressed genes had been primarily categorized into immune system processes, the extracellular area, and the extracellular matrix.
Among the many upregulated genes, 4 genes had been chosen for affirmation utilizing quantitative RT-PCR, leading to 100% related expression patterns in microarray and RNA-Seq. This research recognized 502 frequent differentially expressed genes and confirmed that NEIL3 was considerably overexpressed in LUAD samples (P < 0.001). Elevated NEIL3 expression was associated to superior stage, bigger tumor dimension and poor total survival (p < 0.001) in three LUAD cohorts. The proportions of pure T regulatory cells and induced T regulatory cells elevated within the excessive NEIL3 group, whereas these of B cells, Th17 cells and dendritic cells decreased. Gene set enrichment evaluation indicated that NEIL3 could activate cell cycle development and P53 signaling pathway, resulting in poor outcomes.
Musk ketone induces apoptosis of gastric most cancers cells by way of downregulation of sorbin and SH3 area containing 2
Musk ketone exerts antiproliferative results on a number of varieties of most cancers, reminiscent of lung and breast most cancers. Nonetheless, the consequences and underlying mechanisms of motion of musk ketone in gastric most cancers (GC) are poorly understood. The current research aimed to research the consequences of musk ketone in GC cells. The current research indicated that musk ketone exerted important anticancer results on GC cells. The IC50 values of musk ketone had been 4.2 and 10.06 µM in AGS and HGC‑27 cells, respectively. Low dosage of musk ketone considerably suppressed the proliferation and colony formation of AGS and HGC‑27 cells. Cell cycle arrest and apoptosis had been induced by musk ketone.
 25 mm Diameter Solid Titanium Tip |
|
0-120-0015 |
Biologics |
25 mm |
EUR 614 |
 Flat Replaceable Tips 13 mm Diameter Flat Titanium Tip |
|
0-120-0016 |
Biologics |
13 mm |
EUR 86 |
|
Description: use with corresponding Tapped Tips and Tapped Extender Tips |
 Flat Replaceable Tips 19 mm Diameter Flat Titanium Tip |
|
0-120-0017 |
Biologics |
19 mm |
EUR 92 |
|
Description: use with corresponding Tapped Tips and Tapped Extender Tips |
 Flat Replaceable Tips 25 mm Diameter Flat Titanium Tip |
|
0-120-0018 |
Biologics |
25 mm |
EUR 100 |
|
Description: use with corresponding Tapped Tips and Tapped Extender Tips |
 Titanium Cup Tip, 250 ml |
|
0-120-0019 |
Biologics |
250 ml |
EUR 1377 |
|
Description: includes Interface Washers |
) Microtube Tray, 8 Position (for 250 ml Cup Tip) |
|
0-120-0021 |
Biologics |
each |
EUR 113 |
|
Description: includes Interface Washers |
 Continuous Flow Chamber |
|
0-120-0026 |
Biologics |
each |
EUR 774 |
|
Description: includes Interface Washers |
 Interface Washers 1.5” Diameter, 5/Pkg |
|
0-120-003 |
Biologics |
1.5'' Diameter |
EUR 31 |
 13 mm Diameter Solid Titanium Extender Tip |
|
0-120-0032 |
Biologics |
13 mm |
EUR 301 |
 13 mm Diameter Tapped Titanium Extender Tip |
|
0-120-0033 |
Biologics |
13 mm |
EUR 362 |
 19 mm Diameter Solid Titanium Extender Tip |
|
0-120-0034 |
Biologics |
19 mm |
EUR 315 |
 19 mm Diameter Tapped Titanium Extender Tip |
|
0-120-0035 |
Biologics |
19 mm |
EUR 375 |
 25 mm Diameter Solid Titanium Extender Tip |
|
0-120-0036 |
Biologics |
25 mm |
EUR 328 |
 25 mm Diameter Tapped Titanium Extender Tip |
|
0-120-0037 |
Biologics |
25 mm |
EUR 389 |
 KoldPod, 1.5ml Micro Tube |
|
0-120-0038 |
Biologics |
1.5 ml |
EUR 152 |
|
Description: Thermo conductive tube pods |
 KoldPod, 15ml Conical Tube |
|
0-120-0039 |
Biologics |
15 ml |
EUR 275 |
|
Description: Thermo conductive tube pods |
 KoldPod, 50ml Conical Tube |
|
0-120-0040 |
Biologics |
50 ml |
EUR 290 |
|
Description: Thermo conductive tube pods |
 Model 150 V/T Ultrasonic Homogenizer |
|
0-121-0002 |
Biologics |
210-240V/50-60Hz |
EUR 2920 |
|
|
|
Description: Delivers up to 150 Watts of ultrasonic power to the Titanium Tip. The Timer and Duty Cycle function increase preciosion in sample processing processing. |
 Model 300 V/T Ultrasonic Homogenizer |
|
0-122-0002 |
Biologics |
210-240V/50-60Hz |
EUR 3520 |
|
|
|
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip. The Timer and Duty Cycle function increase preciosion in sample. |
 SONABOZ Sound Abating Chamber |
|
0-125-0001 |
Biologics |
each |
EUR 1020 |
|
Description: Reduces cavitational sound emitted during processing. |
 Model 3000 Ultrasonic Homogenizer |
|
0-127-0002 |
Biologics |
210-240V/50-60Hz |
EUR 4120 |
|
|
|
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip and includes an intergrated Sound Abating Chmaber to reduce cavitational sound emitted during processing. The Timer and Duty Cycle function increase preciosion in sample. |
 Model 3000MP Ultrasonic Homogenizer |
|
0-128-0002 |
Biologics |
210-240V/50-60Hz |
EUR 4720 |
|
|
|
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip with preciosion control from a microprocessor and a graphical user interface displayed on a large (145 mm) LCD display. The integrated Sound Abating Chamber reduces cavitational sound emitted during processing. |
 OMNICON® Zone Reader, 210-240V/50-60Hz |
|
0-131-0002 |
Biologics |
210-240V/50-60Hz |
EUR 35200 |
|
|
|
Description: Designed to Perform multi-plate Assays on round 90/100mm Petri Dishes. The integrated LED illumination system provides transmitted light for brightfield and darkfield illumination of transparent media. |
 OMNI-Noculator Peni Cylinder Filler, 210-240V/50-60Hz |
|
0-134-0002 |
Biologics |
210-240V/50-60Hz |
EUR 32200 |
|
|
|
Description: A robotic liquid handling system designed to dispense Peni Cylinders and fill Peni Cylinders with the corresponding antibiotic liquid sample. |
 Peni Cylinder Dispenser with Manual Hopper |
|
0-144-0002 |
Biologics |
each |
EUR 5406 |
|
|
|
Description: Dispenser can be configured to dispense 4 or 6 Peni Cylinders onto a petri dish. |
 Peni Cylinder Dispenser with Motorized Hopper, 100-240V/50-60Hz |
|
0-144-0003 |
Biologics |
100-240V/50-60Hz |
EUR 6254 |
|
Description: The motorized hopper can be configured to dispense 4 or 6 Peni Cylinders onto a petri Dispenser can be disassembled for disinfection. |
 Stainless Steel Peni Cylinder with Flat Face |
|
0-144-0005 |
Biologics |
6mm I.D. x 8mm O.D. x 10mm Long |
EUR 399 |
|
Description: sold in packages of 100 pieces |
 Stainless Steel Peni Cylinder with Chamfered Face |
|
0-144-0006 |
Biologics |
6mm I.D. x 8mm O.D. x 10mm Long |
EUR 412 |
|
Description: sold in packages of 100 pieces |
) Custom development of ELISAs for other species or antibody isotypes not listed in the catalog. Custom testing of samples for IgG/IgM/IgA or total (IgG+IgM+IgA) |
|
000-CUS |
Alpha Diagnostics |
Custom |
EUR 602 |
 Alpha-Bungarotoxin, CF®405S, 500 ug |
|
00002 |
Biotium |
1UG |
EUR 527 |
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
 Alpha-bungarotoxin, CF405s |
|
00002 |
Cusabio |
500uG |
EUR 594 |
|
Description: Minimum order quantity: 1 unit of 500uG |
Alpha-Bungarotoxin, CF®405S, 500 ug |
|
00002-1 |
Biotium |
EA |
EUR 527 |
 Alpha-Bungarotoxin, CF®405S 100ug |
|
00002-100ug |
Biotium |
100uG |
EUR 132 |
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
 Alpha-Bungarotoxin, CF®680R, 500 ug |
|
9-00003 |
Biotium |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®680R, 500 ug |
|
00003-1 |
Biotium |
EA |
EUR 527 |
 Alpha-Bungarotoxin, CF®680R 100ug |
|
9-00003 |
Biotium |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
 Alpha-Bungarotoxin, CF®640R, 500 ug |
|
9-00004 |
Biotium |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®640R, 500 ug |
|
00004-1 |
Biotium |
EA |
EUR 527 |
 Alpha-Bungarotoxin, CF®640R 100ug |
|
9-00004 |
Biotium |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
 Alpha-Bungarotoxin, CF®488A, 500 ug |
|
9-00005 |
Biotium |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®488A, 500 ug |
|
00005-1 |
Biotium |
EA |
EUR 527 |
 Alpha-Bungarotoxin CF®488A 100ug |
|
9-00005 |
Biotium |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
 Alpha-Bungarotoxin, CF®568, 500 ug |
|
9-00006 |
Biotium |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®568, 500 ug |
|
00006-1 |
Biotium |
EA |
EUR 527 |
 Alpha-Bungarotoxin, CF®568 100ug |
|
9-00006 |
Biotium |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
 Alpha-Bungarotoxin, CF®594, 500 ug |
|
9-00007 |
Biotium |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®594, 500 ug |
|
00007-1 |
Biotium |
EA |
EUR 527 |
 Alpha-Bungarotoxin CF®594 100ug |
|
9-00007 |
Biotium |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
 Alpha-Bungarotoxin, CF®633, 500 ug |
|
9-00009 |
Biotium |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®633, 500 ug |
|
00009-1 |
Biotium |
EA |
EUR 527 |
 Alpha-Bungarotoxin, CF®633 100ug |
|
9-00009 |
Biotium |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
 SARS-CoV-2 Indicator Cell Line for RNA Replication - GFP Reporter only |
|
0001-PP-001 |
IBT Bioservices |
1 cell line (can order x amount) |
EUR 12000 |
|
Description: SARS-CoV-2 GFP reporter cell line using HEK293T (ACE2/TMPRSS2) cells |
 Alpha-Bungarotoxin, 1 mg |
|
00010-1 |
Biotium |
1MG |
EUR 193 |
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, 1 mg |
|
00010-1-1 |
Biotium |
EA |
EUR 193 |
 Fluorescein-Alpha-Bungarotoxin, 500 ug |
|
00011 |
Biotium |
500uG |
EUR 376 |
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Fluorescein-Alpha-Bungarotoxin, 500 ug |
|
00011-1 |
Biotium |
EA |
EUR 376 |
 Tetramethylrhodamine-Alpha-Bungarotoxin, 500 ug |
|
00012 |
Biotium |
500uG |
EUR 394 |
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Tetramethylrhodamine-Alpha-Bungarotoxin, 500 ug |
|
00012-1 |
Biotium |
EA |
EUR 394 |
 Fluorescein-alpha-bungarotoxin, 10x50ug |
|
00013 |
Biotium |
10ST |
EUR 436 |
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Fluorescein-alpha-bungarotoxin, 10x50ug |
|
00013-1 |
Biotium |
EA |
EUR 436 |
 Tetramethylrhodamine-A-Bungarotoxin, 10x50 ug |
|
00014 |
Biotium |
10ST |
EUR 494 |
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Tetramethylrhodamine-A-Bungarotoxin, 10x50 ug |
|
00014-1 |
Biotium |
EA |
EUR 494 |
 Sulforhodamine 101-Alpha-Bungarotoxin, 500 ug |
|
00015 |
Biotium |
500uG |
EUR 494 |
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Sulforhodamine 101-Alpha-Bungarotoxin, 500 ug |
|
00015-1 |
Biotium |
EA |
EUR 494 |
 Sulforhodamine 101-Alpha-Bungarotoxin, 50 ug |
|
00016 |
Biotium |
10ST |
EUR 560 |
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Sulforhodamine 101-Alpha-Bungarotoxin, 50 ug |
|
00016-1 |
Biotium |
EA |
EUR 560 |
 Biotin-XX-A-Bungarotoxin, 500 ug |
|
00017 |
Biotium |
500uG |
EUR 455 |
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Biotin-XX-A-Bungarotoxin, 500 ug |
|
00017-1 |
Biotium |
EA |
EUR 455 |
 Alpha-Bungarotoxin, CF®555, 500 ug |
|
9-00018 |
Biotium |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®555, 500 ug |
|
00018-1 |
Biotium |
EA |
EUR 527 |
 Alpha-Bungarotoxin, CF®555 100ug |
|
9-00018 |
Biotium |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
 Biotin-cAMP, 1 mg |
|
00020 |
Biotium |
1MG |
EUR 298 |
|
|
|
Description: N/A |
Biotin-cAMP, 1 mg |
|
00020-1 |
Biotium |
20ST |
EUR 298 |
|
|
|
Description: N/A |
 Biotin-cAMP, 50 ug |
|
00020-1-1 |
Biotium |
EA |
EUR 414 |
 Biotin-cGMP, 1 mg |
|
00021 |
Biotium |
1MG |
EUR 331 |
|
|
|
Description: N/A |
Biotin-cGMP, 1 mg |
|
00021-1 |
Biotium |
20ST |
EUR 331 |
|
|
|
Description: N/A |
 Biotin-cGMP, 20x50 ug |
|
00021-1-1 |
Biotium |
EA |
EUR 447 |
 Cyanine 644-cAMP, 1 mg |
|
00022 |
Biotium |
1MG |
EUR 496 |
|
|
|
Description: N/A |
Cyanine 644-cAMP, 1 mg |
|
00022-1 |
Biotium |
20ST |
EUR 496 |
|
|
|
Description: N/A |
 Cyanine 644-cAMP, 20x50 ug |
|
00022-1-1 |
Biotium |
EA |
EUR 647 |
 Fluorescein Methotrexate, Triammonium Salt, 1 mg |
|
00023 |
Biotium |
1MG |
EUR 285 |
|
|
|
Description: N/A |
Fluorescein Methotrexate, Triammonium Salt, 1 mg |
|
00023-1 |
Biotium |
EA |
EUR 285 |
 Staurosporine |
|
00025 |
Biotium |
100uG |
EUR 100 |
|
|
|
Description: N/A |
Staurosporine |
|
00025-1 |
Biotium |
EA |
EUR 100 |
 Alpha-Bungarotoxin, CF®543, 500 ug |
|
00026 |
Biotium |
500uG |
EUR 527 |
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®543, 500 ug |
|
00026-1 |
Biotium |
EA |
EUR 527 |
 Alpha-Bungarotoxin, CF®543, 100 ug |
|
00026-100ug |
Biotium |
1UG |
EUR 132 |
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
 Rhodamine Phalloidin 300U |
|
00027 |
Biotium |
300 |
EUR 364 |
|
|
|
Description: N/A |
Rhodamine Phalloidin 300U |
|
00027-1 |
Biotium |
EA |
EUR 364 |
 Biotin-XX-Phalloidin |
|
00028 |
Biotium |
100U |
EUR 466 |
|
|
|
Description: N/A |
Biotin-XX-Phalloidin |
|
00028-1 |
Biotium |
EA |
EUR 466 |
 Fluorescein-Phalloidin |
|
00030 |
Biotium |
300U |
EUR 364 |
|
|
|
Description: N/A |
Fluorescein-Phalloidin |
|
00030-1 |
Biotium |
EA |
EUR 364 |
 Rhodamine 110 Phalloidin |
|
00032 |
Biotium |
300ST |
EUR 364 |
|
|
|
Description: N/A |
Rhodamine 110 Phalloidin |
|
00032-1 |
Biotium |
EA |
EUR 364 |
 Phalloidin) Sulforhodamine 101 (Texas Red®) Phalloidin |
|
00033 |
Biotium |
300EU |
EUR 364 |
|
|
|
Description: N/A |
Sulforhodamine 101 (Texas Red®) Phalloidin |
|
00033-1 |
Biotium |
EA |
EUR 364 |
 Phalloidin, CF®405M |
|
00034 |
Biotium |
300U |
EUR 482 |
|
|
|
Description: N/A |
Phalloidin, CF®405M |
|
00034-1 |
Biotium |
EA |
EUR 482 |
Phalloidin, CF®405M |
|
00034-T |
Biotium |
50U |
EUR 101 |
|
|
|
Description: N/A |
Phalloidin, CF®405M |
|
00034-T-1 |
Biotium |
EA |
EUR 101 |
 CF®488A-cAMP |
|
00036 |
Biotium |
100ug |
EUR 136 |
|
|
|
Description: N/A |
CF®488A-cAMP |
|
00036-1 |
Biotium |
EA |
EUR 136 |
 CF®640R-cAMP |
|
00037 |
Biotium |
100ug |
EUR 136 |
|
|
|
Description: N/A |
CF®640R-cAMP |
|
00037-1 |
Biotium |
EA |
EUR 136 |
 Phalloidin, CF555 |
|
00040 |
Biotium |
300U |
EUR 530.4 |
|
Description: Minimum order quantity: 1 unit of 300U |
Phalloidin, CF555 |
|
00040-T |
Biotium |
50U |
EUR 159.6 |
|
Description: Minimum order quantity: 1 unit of 50U |
 Phalloidin, CF®647, 300 U |
|
00041 |
Biotium |
300U |
EUR 482 |
|
|
|
Description: N/A |
Phalloidin, CF®647, 300 U |
|
00041-1 |
Biotium |
EA |
EUR 482 |
 Phalloidin, CF®647, 50 U |
|
00041-T |
Biotium |
50U |
EUR 101 |
|
|
|
Description: N/A |
Phalloidin, CF®647, 50 U |
|
00041-T-1 |
Biotium |
EA |
EUR 101 |
 Phalloidin, CF®488A, 300 U |
|
00042 |
Biotium |
300U |
EUR 482 |
|
|
|
Description: N/A |
Phalloidin, CF®488A, 300 U |
|
00042-1 |
Biotium |
EA |
EUR 482 |
 Phalloidin, CF®488A, 50 U |
|
00042-T |
Biotium |
50U |
EUR 101 |
|
|
|
Description: N/A |
Phalloidin, CF®488A, 50 U |
|
00042-T-1 |
Biotium |
EA |
EUR 101 |
 Phalloidin, CF®543, 300 U |
|
00043 |
Biotium |
300U |
EUR 482 |
|
|
|
Description: N/A |
Phalloidin, CF®543, 300 U |
|
00043-1 |
Biotium |
EA |
EUR 482 |
 Phalloidin, CF®543, 50 U |
|
00043-T |
Biotium |
50U |
EUR 101 |
|
|
|
Description: N/A |
Phalloidin, CF®543, 50 U |
|
00043-T-1 |
Biotium |
EA |
EUR 101 |
 Phalloidin, CF®568, 300 U |
|
00044 |
Biotium |
300U |
EUR 482 |
|
|
|
Description: N/A |
Moreover, microarray information indicated that musk ketone remedy led to downregulation of varied genes, together with sorbin and SH3 area containing 2 (SORBS2). Reverse transcription‑quantitative PCR and immunoblotting outcomes indicated that musk ketone repressed mRNA and protein expression ranges of SORBS2. It was additionally proven that knockdown of SORBS2 inhibited the proliferation and colony formation of HGC‑27 cells. The antiproliferative results of musk ketone had been decreased in HGC‑27 cells with SORBS2 silencing. In abstract, the current research indicated that musk ketone suppressed the proliferation and progress of GC partly by downregulating SORBS2 expression.
