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Bioinformatic analysis identifying FGF1 gene as a new prognostic indicator in clear cell Renal Cell Carcinoma

Bioinformatic analysis identifying FGF1 gene as a new prognostic indicator in clear cell Renal Cell Carcinoma

Posted on May 10, 2021April 23, 2021 by Vawter
Clear cell renal cell carcinoma (ccRCC) has been the most typical renal cell carcinoma (RCC). Though the illness classification, prognosis and focused remedy of RCC has been more and more evolving attributing to the fast growth of present molecular pathology, the present scientific therapy state of affairs continues to be difficult contemplating the great and progressively growing nature of malignant most cancers. The examine is to establish extra potential accountable genes throughout the growth of ccRCC utilizing bioinformatic evaluation, thus aiding extra exact interpretation of the illness
Firstly, totally different cDNA expression profiles from Gene Expression Omnibus (GEO) on-line database have been used to display the irregular in another way expressed genes (DEGs) between ccRCC and regular renal tissues. Then, primarily based on the protein-protein interplay community (PPI) of all DEGs, the module evaluation was carried out to scale down the potential genes, and additional survival evaluation assisted our continuing to the subsequent step for choosing a reputable key gene.  Lastly, the potential organic perform of the gene and signaling mechanism of gene regulating ccRCC growth was preliminary explored.
4 cDNA expression profiles have been picked from GEO database primarily based on the variety of containing pattern circumstances, and a complete of 192 DEGs, together with 39 up-regulated and 153 down-regulated genes have been shared in 4 profiles. Based mostly on the DEGs PPI community, 4 perform modules have been recognized highlighting a FGF1 gene involving PI3K-AKT signaling pathway which was shared in 3/Four modules. Additional, each the IHC carried out with ccRCC tissue microarray which contained 104 native samples and QPCR performed utilizing 30 totally different samples confirmed that FGF1 was aberrant misplaced in ccRCC.
And Kaplan-Meier total survival evaluation revealed that FGF1 gene loss was associated to worse ccRCC sufferers survival. Lastly, the pathological scientific options of FGF1 gene and the possible organic capabilities and signaling pathways it concerned have been analyzed utilizing TCGA scientific information. Utilizing bioinformatic evaluation, we revealed that FGF1 expression was aberrant misplaced in ccRCC which statistical considerably correlated with sufferers total survival, and the gene’s scientific options and potential organic capabilities have been additionally explored. Nonetheless, extra detailed experiments and scientific trials are wanted to help its potential drug-target function in scientific medical use.

microR-4449 Promotes Colorectal Most cancers Cell Proliferation through Regulation of SOCS3 and Activation of STAT3 Signaling

The microarray information of GSE115513 have been retrieved; subsequently, the differentially expressed miRNAs between 411 colon tumors and 381 regular colon mucosa have been analyzed. Actual-time PCR (RT-qPCR) and bioinformatic evaluation have been utilized to look at the expression of miR-4449 in collected colorectal tumors and printed microarray information. The exercise of sign transducer and activator of transcription 3 (STAT3) signaling was detected by Western blotting and RT-qPCR. Twin-Luciferase assay and bioinformatic evaluation have been used to verify the interplay between suppressor of cytokine signaling 3 (SOCS3) and miR-4449.

Lack of perform and rescue assays have been carried out to review the involvement of miR-4449 and SOCS3 in cell proliferation and apoptosis of colorectal most cancers. Herein, we recognized miR-4449 as a novel upregulated miRNA in colorectal most cancers. Our information advised that miR-4449 downregulation blocked the proliferation of colorectal most cancers cells accompanied with the elevation of cell apoptosis. Thirdly, immunohistochemistry (IHC) and quantitative real-time PCR (QPCR) have been performed to validate the expression change of the important thing gene in ccRCC evaluating to regular tissues, in the meantime the prognostic worth was verified utilizing TCGA scientific information.

Decreased expression of miR-4449 led to inactivation of STAT3 pathway as indicated by dephosphorylation of STAT3 and downregulation of STAT3 goal genes, together with vascular endothelial development issue (VEGF), c-Myc, baculovirus inhibitor of apoptosis containing 5 (BIRC5). Moreover, SOCS3, a detrimental regulator of STAT3 pathway, was discovered to be a goal gene of miR-4449. The info additionally confirmed that the inactivation of STAT3 pathway by miR-4449 inhibitor was realized by focusing on SOCS3. Furthermore, the organic perform of miR-4449 downregulation was reversed by SOCS3 knockdown in colorectal most cancers cells.

Bioinformatic analysis identifying FGF1 gene as a new prognostic indicator in clear cell Renal Cell Carcinoma

Inhibition of syndecan-Four reduces cartilage degradation in murine fashions of osteoarthritis by way of the downregulation of HIF-2α by miR-96-5p

The membranous receptor syndecan-4 (SDC-4) and the nuclear transcription issue hypoxia-induced factor-2α (HIF-2α) play vital roles within the pathogenesis of osteoarthritis (OA). The purpose of this examine was to find out whether or not SDC-Four inhibition downregulates HIF-2a expression by microRNA-96-5p (miR-96-5p) in murine chondrocyte and cartilage tissue. The OA mannequin was induced surgically in mice, and SDC-Four polyclonal antibody, HIF-2α small interfering RNA (siRNA) and its management, miR-96-5p mimics and its scrambled controls or anti-miR-96-5p and its management have been then injected into the knee joints.

At 2 and Four weeks after surgical procedure, OA development was evaluated microscopically, histologically, radiographically and immunohistochemically in these mice. Actual-time polymerase chain response (RT-PCR) and western blotting have been carried out after treating with antibody and transfecting with miRNA mimic or siRNA to find out their results on OA-related mediators. The potential miRNAs associated to OA growth have been recognized through the use of miRNA microarray evaluation. Whether or not miRNAs play a pivotal function in OA growth in vivo or in vitro was additionally investigated.

19 mm Diameter Tapped Titanium Tip

0-120-0012 Biologics 19 mm
EUR 639

19 mm Diameter Solid Titanium Tip

0-120-0013 Biologics 19 mm
EUR 570

25 mm Diameter Tapped Titanium Tip

0-120-0014 Biologics 25 mm
EUR 682

25 mm Diameter Solid Titanium Tip

0-120-0015 Biologics 25 mm
EUR 614

Flat Replaceable Tips 13 mm Diameter Flat Titanium Tip

0-120-0016 Biologics 13 mm
EUR 86
Description: use with corresponding Tapped Tips and Tapped Extender Tips

Flat Replaceable Tips 19 mm Diameter Flat Titanium Tip

0-120-0017 Biologics 19 mm
EUR 92
Description: use with corresponding Tapped Tips and Tapped Extender Tips

Flat Replaceable Tips 25 mm Diameter Flat Titanium Tip

0-120-0018 Biologics 25 mm
EUR 100
Description: use with corresponding Tapped Tips and Tapped Extender Tips

Titanium Cup Tip, 250 ml

0-120-0019 Biologics 250 ml
EUR 1377
Description: includes Interface Washers

Microtube Tray, 8 Position (for 250 ml Cup Tip)

0-120-0021 Biologics each
EUR 113
Description: includes Interface Washers

Continuous Flow Chamber

0-120-0026 Biologics each
EUR 774
Description: includes Interface Washers

Interface Washers 1.5” Diameter, 5/Pkg

0-120-003 Biologics 1.5'' Diameter
EUR 31

13 mm Diameter Solid Titanium Extender Tip

0-120-0032 Biologics 13 mm
EUR 301

13 mm Diameter Tapped Titanium Extender Tip

0-120-0033 Biologics 13 mm
EUR 362

19 mm Diameter Solid Titanium Extender Tip

0-120-0034 Biologics 19 mm
EUR 315

19 mm Diameter Tapped Titanium Extender Tip

0-120-0035 Biologics 19 mm
EUR 375

25 mm Diameter Solid Titanium Extender Tip

0-120-0036 Biologics 25 mm
EUR 328

25 mm Diameter Tapped Titanium Extender Tip

0-120-0037 Biologics 25 mm
EUR 389

KoldPod, 1.5ml Micro Tube

0-120-0038 Biologics 1.5 ml
EUR 152
Description: Thermo conductive tube pods

KoldPod, 15ml Conical Tube

0-120-0039 Biologics 15 ml
EUR 275
Description: Thermo conductive tube pods

KoldPod, 50ml Conical Tube

0-120-0040 Biologics 50 ml
EUR 290
Description: Thermo conductive tube pods

Model 150 V/T Ultrasonic Homogenizer

0-121-0002 Biologics 210-240V/50-60Hz
EUR 2920
Description: Delivers up to 150 Watts of ultrasonic power to the Titanium Tip. The Timer and Duty Cycle function increase preciosion in sample processing processing.

Model 300 V/T Ultrasonic Homogenizer

0-122-0002 Biologics 210-240V/50-60Hz
EUR 3520
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip. The Timer and Duty Cycle function increase preciosion in sample.

SONABOZ Sound Abating Chamber

0-125-0001 Biologics each
EUR 1020
Description: Reduces cavitational sound emitted during processing.

Model 3000 Ultrasonic Homogenizer

0-127-0002 Biologics 210-240V/50-60Hz
EUR 4120
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip and includes an intergrated Sound Abating Chmaber to reduce cavitational sound emitted during processing. The Timer and Duty Cycle function increase preciosion in sample.

Model 3000MP Ultrasonic Homogenizer

0-128-0002 Biologics 210-240V/50-60Hz
EUR 4720
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip with preciosion control from a microprocessor and a graphical user interface displayed on a large (145 mm) LCD display. The integrated Sound Abating Chamber reduces cavitational sound emitted during processing.

OMNICON® Zone Reader, 210-240V/50-60Hz

0-131-0002 Biologics 210-240V/50-60Hz
EUR 35200
Description: Designed to Perform multi-plate Assays on round 90/100mm Petri Dishes. The integrated LED illumination system provides transmitted light for brightfield and darkfield illumination of transparent media.

OMNI-Noculator Peni Cylinder Filler, 210-240V/50-60Hz

0-134-0002 Biologics 210-240V/50-60Hz
EUR 32200
Description: A robotic liquid handling system designed to dispense Peni Cylinders and fill Peni Cylinders with the corresponding antibiotic liquid sample.

Peni Cylinder Dispenser with Manual Hopper

0-144-0002 Biologics each
EUR 5406
Description: Dispenser can be configured to dispense 4 or 6 Peni Cylinders onto a petri dish.

Peni Cylinder Dispenser with Motorized Hopper, 100-240V/50-60Hz

0-144-0003 Biologics 100-240V/50-60Hz
EUR 6254
Description: The motorized hopper can be configured to dispense 4 or 6 Peni Cylinders onto a petri Dispenser can be disassembled for disinfection.

Stainless Steel Peni Cylinder with Flat Face

0-144-0005 Biologics 6mm I.D. x 8mm O.D. x 10mm Long
EUR 399
Description: sold in packages of 100 pieces

Stainless Steel Peni Cylinder with Chamfered Face

0-144-0006 Biologics 6mm I.D. x 8mm O.D. x 10mm Long
EUR 412
Description: sold in packages of 100 pieces

Custom development of ELISAs for other species or antibody isotypes not listed in the catalog. Custom testing of samples for IgG/IgM/IgA or total (IgG+IgM+IgA)

000-CUS Alpha Diagnostics Custom
EUR 602

Alpha-Bungarotoxin, CF®405S, 500 ug

00002 Biotium 1UG
EUR 527
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-bungarotoxin, CF405s

00002 Cusabio 500uG
EUR 594
Description: Minimum order quantity: 1 unit of 500uG

Alpha-Bungarotoxin, CF®405S, 500 ug

00002-1 Biotium EA
EUR 527

Alpha-Bungarotoxin, CF®405S 100ug

00002-100ug Biotium 100uG
EUR 132
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®680R, 500 ug

9-00003 Biotium
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®680R, 500 ug

00003-1 Biotium EA
EUR 527

Alpha-Bungarotoxin, CF®680R 100ug

9-00003 Biotium
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®640R, 500 ug

9-00004 Biotium
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®640R, 500 ug

00004-1 Biotium EA
EUR 527

Alpha-Bungarotoxin, CF®640R 100ug

9-00004 Biotium
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®488A, 500 ug

9-00005 Biotium
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®488A, 500 ug

00005-1 Biotium EA
EUR 527

Alpha-Bungarotoxin CF®488A 100ug

9-00005 Biotium
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®568, 500 ug

9-00006 Biotium
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®568, 500 ug

00006-1 Biotium EA
EUR 527

Alpha-Bungarotoxin, CF®568 100ug

9-00006 Biotium
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®594, 500 ug

9-00007 Biotium
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®594, 500 ug

00007-1 Biotium EA
EUR 527

Alpha-Bungarotoxin CF®594 100ug

9-00007 Biotium
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®633, 500 ug

9-00009 Biotium
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®633, 500 ug

00009-1 Biotium EA
EUR 527

Alpha-Bungarotoxin, CF®633 100ug

9-00009 Biotium
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

SARS-CoV-2 Indicator Cell Line for RNA Replication - GFP Reporter only

0001-PP-001 IBT Bioservices 1 cell line (can order x amount)
EUR 12000
Description: SARS-CoV-2 GFP reporter cell line using HEK293T (ACE2/TMPRSS2) cells

Alpha-Bungarotoxin, 1 mg

00010-1 Biotium 1MG
EUR 193
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, 1 mg

00010-1-1 Biotium EA
EUR 193

Fluorescein-Alpha-Bungarotoxin, 500 ug

00011 Biotium 500uG
EUR 376
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Fluorescein-Alpha-Bungarotoxin, 500 ug

00011-1 Biotium EA
EUR 376

Tetramethylrhodamine-Alpha-Bungarotoxin, 500 ug

00012 Biotium 500uG
EUR 394
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Tetramethylrhodamine-Alpha-Bungarotoxin, 500 ug

00012-1 Biotium EA
EUR 394

Fluorescein-alpha-bungarotoxin, 10x50ug

00013 Biotium 10ST
EUR 436
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Fluorescein-alpha-bungarotoxin, 10x50ug

00013-1 Biotium EA
EUR 436

Tetramethylrhodamine-A-Bungarotoxin, 10x50 ug

00014 Biotium 10ST
EUR 494
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Tetramethylrhodamine-A-Bungarotoxin, 10x50 ug

00014-1 Biotium EA
EUR 494

Sulforhodamine 101-Alpha-Bungarotoxin, 500 ug

00015 Biotium 500uG
EUR 494
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Sulforhodamine 101-Alpha-Bungarotoxin, 500 ug

00015-1 Biotium EA
EUR 494

Sulforhodamine 101-Alpha-Bungarotoxin, 50 ug

00016 Biotium 10ST
EUR 560
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Sulforhodamine 101-Alpha-Bungarotoxin, 50 ug

00016-1 Biotium EA
EUR 560

Biotin-XX-A-Bungarotoxin, 500 ug

00017 Biotium 500uG
EUR 455
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Biotin-XX-A-Bungarotoxin, 500 ug

00017-1 Biotium EA
EUR 455

Alpha-Bungarotoxin, CF®555, 500 ug

9-00018 Biotium
  • Ask for price
  • Ask for price
  • 500uG
  • 100ug
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®555, 500 ug

00018-1 Biotium EA
EUR 527

Alpha-Bungarotoxin, CF®555 100ug

9-00018 Biotium
  • Ask for price
  • Ask for price
  • 500uG
  • 100ug
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Acrylamide, Chemzymes Ultra Pure®

00019-100 Polysciences Europe GmbH 100g
EUR 101.52
Description: 79-06-1

Acrylamide, Chemzymes Ultra Pure®

00019-500 Polysciences Europe GmbH 500g
EUR 270
Description: 79-06-1

Biotin-cAMP, 1 mg

00020 Biotium 1MG
EUR 298
Description: N/A

Biotin-cAMP, 1 mg

00020-1 Biotium 20ST
EUR 298
Description: N/A

Biotin-cAMP, 50 ug

00020-1-1 Biotium EA
EUR 414

Biotin-cGMP, 1 mg

00021 Biotium 1MG
EUR 331
Description: N/A

Biotin-cGMP, 1 mg

00021-1 Biotium 20ST
EUR 331
Description: N/A

Biotin-cGMP, 20x50 ug

00021-1-1 Biotium EA
EUR 447

Cyanine 644-cAMP, 1 mg

00022 Biotium 1MG
EUR 496
Description: N/A

Cyanine 644-cAMP, 1 mg

00022-1 Biotium 20ST
EUR 496
Description: N/A

Cyanine 644-cAMP, 20x50 ug

00022-1-1 Biotium EA
EUR 647

Fluorescein Methotrexate, Triammonium Salt, 1 mg

00023 Biotium 1MG
EUR 285
Description: N/A

Fluorescein Methotrexate, Triammonium Salt, 1 mg

00023-1 Biotium EA
EUR 285

Staurosporine

00025 Biotium 100uG
EUR 100
Description: N/A

Staurosporine

00025-1 Biotium EA
EUR 100

Alpha-Bungarotoxin, CF®543, 500 ug

00026 Biotium 500uG
EUR 527
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®543, 500 ug

00026-1 Biotium EA
EUR 527

Alpha-Bungarotoxin, CF®543, 100 ug

00026-100ug Biotium 1UG
EUR 132
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Rhodamine Phalloidin 300U

00027 Biotium 300
EUR 364
Description: N/A

Rhodamine Phalloidin 300U

00027-1 Biotium EA
EUR 364

Biotin-XX-Phalloidin

00028 Biotium 100U
EUR 466
Description: N/A

Biotin-XX-Phalloidin

00028-1 Biotium EA
EUR 466

Fluorescein-Phalloidin

00030 Biotium 300U
EUR 364
Description: N/A

Fluorescein-Phalloidin

00030-1 Biotium EA
EUR 364

Rhodamine 110 Phalloidin

00032 Biotium 300ST
EUR 364
Description: N/A

Rhodamine 110 Phalloidin

00032-1 Biotium EA
EUR 364

Sulforhodamine 101 (Texas Red®) Phalloidin

00033 Biotium 300EU
EUR 364
Description: N/A

Sulforhodamine 101 (Texas Red®) Phalloidin

00033-1 Biotium EA
EUR 364

Phalloidin, CF®405M

00034 Biotium 300U
EUR 482
Description: N/A

Phalloidin, CF®405M

00034-1 Biotium EA
EUR 482

Phalloidin, CF®405M

00034-T Biotium 50U
EUR 101
Description: N/A

Phalloidin, CF®405M

00034-T-1 Biotium EA
EUR 101

CF®488A-cAMP

00036 Biotium 100ug
EUR 136
Description: N/A

CF®488A-cAMP

00036-1 Biotium EA
EUR 136

CF®640R-cAMP

00037 Biotium 100ug
EUR 136
Description: N/A

CF®640R-cAMP

00037-1 Biotium EA
EUR 136

Phalloidin, CF555

00040 Biotium 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF555

00040-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF®647, 300 U

00041 Biotium 300U
EUR 482
Description: N/A

Phalloidin, CF®647, 300 U

00041-1 Biotium EA
EUR 482

Phalloidin, CF®647, 50 U

00041-T Biotium 50U
EUR 101
Description: N/A

Phalloidin, CF®647, 50 U

00041-T-1 Biotium EA
EUR 101

Phalloidin, CF®488A, 300 U

00042 Biotium 300U
EUR 482
Description: N/A

Phalloidin, CF®488A, 300 U

00042-1 Biotium EA
EUR 482

Phalloidin, CF®488A, 50 U

00042-T Biotium 50U
EUR 101
Description: N/A

Phalloidin, CF®488A, 50 U

00042-T-1 Biotium EA
EUR 101

Phalloidin, CF®543, 300 U

00043 Biotium 300U
EUR 482
Description: N/A

Phalloidin, CF®543, 300 U

00043-1 Biotium EA
EUR 482

Phalloidin, CF®543, 50 U

00043-T Biotium 50U
EUR 101
Description: N/A

Phalloidin, CF®543, 50 U

00043-T-1 Biotium EA
EUR 101

Phalloidin, CF®568, 300 U

00044 Biotium 300U
EUR 482
Description: N/A

Phalloidin, CF®568, 300 U

00044-1 Biotium EA
EUR 482

Phalloidin, CF®568, 50 U

00044-T Biotium 50U
EUR 101
Description: N/A

Phalloidin, CF®568, 50 U

00044-T-1 Biotium EA
EUR 101

Phalloidin, CF®594, 300 U

00045 Biotium 300U
EUR 482
Description: N/A

Phalloidin, CF®594, 300 U

00045-1 Biotium EA
EUR 482

Phalloidin, CF®594, 50 U

00045-T Biotium 50U
EUR 101
Description: N/A

Phalloidin, CF®594, 50 U

00045-T-1 Biotium EA
EUR 101

Phalloidin, CF®633, 300 U

00046 Biotium 300U
EUR 482
Description: N/A

Phalloidin, CF®633, 300 U

00046-1 Biotium EA
EUR 482

Phalloidin, CF®633, 50 U

00046-T Biotium 50U
EUR 101
Description: N/A

Phalloidin, CF®633, 50 U

00046-T-1 Biotium EA
EUR 101

Phalloidin, CF®660R, 300 U

00047 Biotium 300U
EUR 482
Description: N/A

Phalloidin, CF®660R, 300 U

00047-1 Biotium EA
EUR 482

Phalloidin, CF®660R, 50 U

00047-T Biotium 50U
EUR 101
Description: N/A

Phalloidin, CF®660R, 50 U

00047-T-1 Biotium EA
EUR 101

Phalloidin, CF®680R, 300 U

00048 Biotium 300U
EUR 513
Description: N/A

Phalloidin, CF®680R, 300 U

00048-1 Biotium EA
EUR 513
×

MiR-96-5p expression was upregulated by SDC-4-specific antibodies in chondrocytes and cartilage tissue, and miR-96-5p instantly focused the three’-UTR of HIF-2α to inhibit HIF-2α signaling in murine chondrocytes. Furthermore, we demonstrated that anti-SDC-4-attenuated IL-1β-induced chondrocyte hypertrophy and cartilage degradation by inhibiting HIF-2α signaling by a miR-96-5p-dependent mechanism. Our examine revealed that the inhibition of SDC-Four exerts its results on each cartilage homeostasis and the chondrocyte hypertrophy phenotype by inducing miR-96-5p expression, which leads to focusing on HIF-2α 3′-UTR sequences and inhibiting HIF-2α in murine cartilage tissue and chondrocytes.

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Recent Posts

  • PolymorphPrep
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  • Rabies Ag Test Kit
  • Bakkenolide‑IIIa ameliorates lipopolysaccharide‑induced inflammatory injury in human umbilical vein endothelial cells by upregulating LINC00294
  • Human Inflammatory Neutrophils Express Genes Encoding Peptidase Inhibitors: Production of Elafin Mediated by NF-κB and CCAAT/Enhancer-Binding Protein β
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