Clear cell renal cell carcinoma (ccRCC) has been the most typical renal cell carcinoma (RCC). Though the illness classification, prognosis and focused remedy of RCC has been more and more evolving attributing to the fast growth of present molecular pathology, the present scientific therapy state of affairs continues to be difficult contemplating the great and progressively growing nature of malignant most cancers. The examine is to establish extra potential accountable genes throughout the growth of ccRCC utilizing bioinformatic evaluation, thus aiding extra exact interpretation of the illness
Firstly, totally different cDNA expression profiles from Gene Expression Omnibus (GEO) on-line database have been used to display the irregular in another way expressed genes (DEGs) between ccRCC and regular renal tissues. Then, primarily based on the protein-protein interplay community (PPI) of all DEGs, the module evaluation was carried out to scale down the potential genes, and additional survival evaluation assisted our continuing to the subsequent step for choosing a reputable key gene. Lastly, the potential organic perform of the gene and signaling mechanism of gene regulating ccRCC growth was preliminary explored.
4 cDNA expression profiles have been picked from GEO database primarily based on the variety of containing pattern circumstances, and a complete of 192 DEGs, together with 39 up-regulated and 153 down-regulated genes have been shared in 4 profiles. Based mostly on the DEGs PPI community, 4 perform modules have been recognized highlighting a FGF1 gene involving PI3K-AKT signaling pathway which was shared in 3/Four modules. Additional, each the IHC carried out with ccRCC tissue microarray which contained 104 native samples and QPCR performed utilizing 30 totally different samples confirmed that FGF1 was aberrant misplaced in ccRCC.
And Kaplan-Meier total survival evaluation revealed that FGF1 gene loss was associated to worse ccRCC sufferers survival. Lastly, the pathological scientific options of FGF1 gene and the possible organic capabilities and signaling pathways it concerned have been analyzed utilizing TCGA scientific information. Utilizing bioinformatic evaluation, we revealed that FGF1 expression was aberrant misplaced in ccRCC which statistical considerably correlated with sufferers total survival, and the gene’s scientific options and potential organic capabilities have been additionally explored. Nonetheless, extra detailed experiments and scientific trials are wanted to help its potential drug-target function in scientific medical use.
microR-4449 Promotes Colorectal Most cancers Cell Proliferation through Regulation of SOCS3 and Activation of STAT3 Signaling
The microarray information of GSE115513 have been retrieved; subsequently, the differentially expressed miRNAs between 411 colon tumors and 381 regular colon mucosa have been analyzed. Actual-time PCR (RT-qPCR) and bioinformatic evaluation have been utilized to look at the expression of miR-4449 in collected colorectal tumors and printed microarray information. The exercise of sign transducer and activator of transcription 3 (STAT3) signaling was detected by Western blotting and RT-qPCR. Twin-Luciferase assay and bioinformatic evaluation have been used to verify the interplay between suppressor of cytokine signaling 3 (SOCS3) and miR-4449.
Lack of perform and rescue assays have been carried out to review the involvement of miR-4449 and SOCS3 in cell proliferation and apoptosis of colorectal most cancers. Herein, we recognized miR-4449 as a novel upregulated miRNA in colorectal most cancers. Our information advised that miR-4449 downregulation blocked the proliferation of colorectal most cancers cells accompanied with the elevation of cell apoptosis. Thirdly, immunohistochemistry (IHC) and quantitative real-time PCR (QPCR) have been performed to validate the expression change of the important thing gene in ccRCC evaluating to regular tissues, in the meantime the prognostic worth was verified utilizing TCGA scientific information.
Decreased expression of miR-4449 led to inactivation of STAT3 pathway as indicated by dephosphorylation of STAT3 and downregulation of STAT3 goal genes, together with vascular endothelial development issue (VEGF), c-Myc, baculovirus inhibitor of apoptosis containing 5 (BIRC5). Moreover, SOCS3, a detrimental regulator of STAT3 pathway, was discovered to be a goal gene of miR-4449. The info additionally confirmed that the inactivation of STAT3 pathway by miR-4449 inhibitor was realized by focusing on SOCS3. Furthermore, the organic perform of miR-4449 downregulation was reversed by SOCS3 knockdown in colorectal most cancers cells.
Inhibition of syndecan-Four reduces cartilage degradation in murine fashions of osteoarthritis by way of the downregulation of HIF-2α by miR-96-5p
The membranous receptor syndecan-4 (SDC-4) and the nuclear transcription issue hypoxia-induced factor-2α (HIF-2α) play vital roles within the pathogenesis of osteoarthritis (OA). The purpose of this examine was to find out whether or not SDC-Four inhibition downregulates HIF-2a expression by microRNA-96-5p (miR-96-5p) in murine chondrocyte and cartilage tissue. The OA mannequin was induced surgically in mice, and SDC-Four polyclonal antibody, HIF-2α small interfering RNA (siRNA) and its management, miR-96-5p mimics and its scrambled controls or anti-miR-96-5p and its management have been then injected into the knee joints.
At 2 and Four weeks after surgical procedure, OA development was evaluated microscopically, histologically, radiographically and immunohistochemically in these mice. Actual-time polymerase chain response (RT-PCR) and western blotting have been carried out after treating with antibody and transfecting with miRNA mimic or siRNA to find out their results on OA-related mediators. The potential miRNAs associated to OA growth have been recognized through the use of miRNA microarray evaluation. Whether or not miRNAs play a pivotal function in OA growth in vivo or in vitro was additionally investigated.
Alpha-bungarotoxin, CF680r |
|||
| 9-00003 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 100uG |
|||
Alpha-bungarotoxin, CF640r |
|||
| 9-00004 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 500uG |
|||
Alpha-bungarotoxin, CF640r |
|||
| 9-00004 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 100uG |
|||
Alpha-bungarotoxin, CF488a |
|||
| 9-00005 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 500uG |
|||
Alpha-bungarotoxin CF488a |
|||
| 9-00005 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 100uG |
|||
Alpha-bungarotoxin, CF568 |
|||
| 9-00006 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 500uG |
|||
Alpha-bungarotoxin, CF568 |
|||
| 9-00006 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 100uG |
|||
Alpha-bungarotoxin, CF594 |
|||
| 9-00007 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 500uG |
|||
Alpha-bungarotoxin CF594 |
|||
| 9-00007 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 100uG |
|||
Alpha-bungarotoxin, CF633 |
|||
| 9-00009 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 500uG |
|||
Alpha-bungarotoxin, CF633 |
|||
| 9-00009 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 100uG |
|||
Alpha-bungarotoxin |
|||
| 00010-1 | Biotium | 1MG | EUR 201.6 |
|
Description: Minimum order quantity: 1 unit of 1MG |
|||
Fluorescein-Alpha-bungarotoxin |
|||
| 00011 | Biotium | 500uG | EUR 440.4 |
|
Description: Minimum order quantity: 1 unit of 500uG |
|||
Tetramethylrhodamine-Alpha-bungarotoxin |
|||
| 00012 | Biotium | 500uG | EUR 459.6 |
|
Description: Minimum order quantity: 1 unit of 500uG |
|||
Fluorescein-alpha-bungarotoxin: (10x50ug) |
|||
| 00013 | Biotium | 10ST | EUR 500.4 |
|
Description: Minimum order quantity: 1 unit of 10ST |
|||
Tetramethylrhodamine-alpha-bungarotoxin: (10x50ug) |
|||
| 00014 | Biotium | 10ST | EUR 559.2 |
|
Description: Minimum order quantity: 1 unit of 10ST |
|||
Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (500ug) |
|||
| 00015 | Biotium | 500uG | EUR 559.2 |
|
Description: Minimum order quantity: 1 unit of 500uG |
|||
Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (10x50ug) |
|||
| 00016 | Biotium | 10ST | EUR 627.6 |
|
Description: Minimum order quantity: 1 unit of 10ST |
|||
Biotin-xx-a-bungarotoxin |
|||
| 00017 | Biotium | 500uG | EUR 519.6 |
|
Description: Minimum order quantity: 1 unit of 500uG |
|||
Alpha-Bungarotoxin, CF555 conjugate |
|||
| 9-00018 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 500uG |
|||
Alpha-Bungarotoxin, CF555 conjugate |
|||
| 9-00018 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 100ug |
|||
Biotin-cAMP, diisopropylethylammonium salt: |
|||
| 00020 | Biotium | 1MG | EUR 376.8 |
|
Description: Minimum order quantity: 1 unit of 1MG |
|||
Biotin-cAMP, diisopropylethylammonium salt: (20x50ug) |
|||
| 00020-1 | Biotium | 20ST | EUR 501.6 |
|
Description: Minimum order quantity: 1 unit of 20ST |
|||
Biotin-cGMP, diisopropylethylammonium salt: |
|||
| 00021 | Biotium | 1MG | EUR 412.8 |
|
Description: Minimum order quantity: 1 unit of 1MG |
|||
Biotin-cGMP, diisopropylethylammonium salt: (20x50ug) |
|||
| 00021-1 | Biotium | 20ST | EUR 537.6 |
|
Description: Minimum order quantity: 1 unit of 20ST |
|||
Cyanine 644-cAMP: |
|||
| 00022 | Biotium | 1MG | EUR 589.2 |
|
Description: Minimum order quantity: 1 unit of 1MG |
|||
Cyanine 644-cAMP: (20x50ug) |
|||
| 00022-1 | Biotium | 20ST | EUR 750 |
|
Description: Minimum order quantity: 1 unit of 20ST |
|||
Fluorescein Methotrexate, triammonium salt: |
|||
| 00023 | Biotium | 1MG | EUR 337.2 |
|
Description: Minimum order quantity: 1 unit of 1MG |
|||
Staurosporine |
|||
| 00025 | Biotium | 100uG | EUR 166.8 |
|
Description: Minimum order quantity: 1 unit of 100uG |
|||
Alpha-bungarotoxin, CF543 |
|||
| 00026 | Biotium | 500uG | EUR 592.8 |
|
Description: Minimum order quantity: 1 unit of 500uG |
|||
Rhodamine phalloidin 300u |
|||
| 00027 | Biotium | 300 | EUR 414 |
|
Description: Minimum order quantity: 1 unit of 300 |
|||
Biotin-xx-phalloidin |
|||
| 00028 | Biotium | 100U | EUR 513.6 |
|
Description: Minimum order quantity: 1 unit of 100U |
|||
Fluorescein-phalloidin |
|||
| 00030 | Biotium | 300U | EUR 414 |
|
Description: Minimum order quantity: 1 unit of 300U |
|||
Rhodamine 110 phalloidin |
|||
| 00032 | Biotium | 300ST | EUR 414 |
|
Description: Minimum order quantity: 1 unit of 300ST |
|||
Sulforhodamine 101 (Texas-Red) Phalloidin |
|||
| 00033 | Biotium | 300EU | EUR 414 |
|
Description: Minimum order quantity: 1 unit of 300EU |
|||
Phalloidin, CF405M |
|||
| 00034 | Biotium | 300U | EUR 530.4 |
|
Description: Minimum order quantity: 1 unit of 300U |
|||
Phalloidin, CF405M |
|||
| 00034-T | Biotium | 50U | EUR 159.6 |
|
Description: Minimum order quantity: 1 unit of 50U |
|||
CF488A-cAMP |
|||
| 00036 | Biotium | 100ug | EUR 206.4 |
|
Description: Minimum order quantity: 1 unit of 100ug |
|||
CF640R-cAMP |
|||
| 00037 | Biotium | 100ug | EUR 206.4 |
|
Description: Minimum order quantity: 1 unit of 100ug |
|||
Phalloidin, CF555 |
|||
| 00040 | Biotium | 300U | EUR 530.4 |
|
Description: Minimum order quantity: 1 unit of 300U |
|||
Phalloidin, CF555 |
|||
| 00040-T | Biotium | 50U | EUR 159.6 |
|
Description: Minimum order quantity: 1 unit of 50U |
|||
Phalloidin, CF647 |
|||
| 00041 | Biotium | 300U | EUR 530.4 |
|
Description: Minimum order quantity: 1 unit of 300U |
|||
Phalloidin, CF647 |
|||
| 00041-T | Biotium | 50U | EUR 159.6 |
|
Description: Minimum order quantity: 1 unit of 50U |
|||
Phalloidin, CF488A |
|||
| 00042 | Biotium | 300U | EUR 530.4 |
|
Description: Minimum order quantity: 1 unit of 300U |
|||
Phalloidin, CF488A |
|||
| 00042-T | Biotium | 50U | EUR 159.6 |
|
Description: Minimum order quantity: 1 unit of 50U |
|||
Phalloidin, CF543 |
|||
| 00043 | Biotium | 300U | EUR 530.4 |
|
Description: Minimum order quantity: 1 unit of 300U |
|||
Phalloidin, CF543 |
|||
| 00043-T | Biotium | 50U | EUR 159.6 |
|
Description: Minimum order quantity: 1 unit of 50U |
|||
Phalloidin, CF568 |
|||
| 00044 | Biotium | 300U | EUR 530.4 |
|
Description: Minimum order quantity: 1 unit of 300U |
|||
Phalloidin, CF568 |
|||
| 00044-T | Biotium | 50U | EUR 159.6 |
|
Description: Minimum order quantity: 1 unit of 50U |
|||
Phalloidin, CF594 |
|||
| 00045 | Biotium | 300U | EUR 530.4 |
|
Description: Minimum order quantity: 1 unit of 300U |
|||
Phalloidin, CF594 |
|||
| 00045-T | Biotium | 50U | EUR 159.6 |
|
Description: Minimum order quantity: 1 unit of 50U |
|||
Phalloidin, CF633 |
|||
| 00046 | Biotium | 300U | EUR 530.4 |
|
Description: Minimum order quantity: 1 unit of 300U |
|||
Phalloidin, CF633 |
|||
| 00046-T | Biotium | 50U | EUR 159.6 |
|
Description: Minimum order quantity: 1 unit of 50U |
|||
Phalloidin, CF660R |
|||
| 00047 | Biotium | 300U | EUR 530.4 |
|
Description: Minimum order quantity: 1 unit of 300U |
|||
Phalloidin, CF660R |
|||
| 00047-T | Biotium | 50U | EUR 159.6 |
|
Description: Minimum order quantity: 1 unit of 50U |
|||
Phalloidin, CF680R |
|||
| 00048 | Biotium | 300U | EUR 559.2 |
|
Description: Minimum order quantity: 1 unit of 300U |
|||
Phalloidin, CF680R |
|||
| 00048-T | Biotium | 50U | EUR 159.6 |
|
Description: Minimum order quantity: 1 unit of 50U |
|||
Phalloidin, CF350 |
|||
| 00049 | Biotium | 300U | EUR 530.4 |
|
Description: Minimum order quantity: 1 unit of 300U |
|||
Phalloidin, CF350 |
|||
| 00049-T | Biotium | 50U | EUR 159.6 |
|
Description: Minimum order quantity: 1 unit of 50U |
|||
Phalloidin, CF640R |
|||
| 00050 | Biotium | 300U | EUR 530.4 |
|
Description: Minimum order quantity: 1 unit of 300U |
|||
Phalloidin, CF640R |
|||
| 00050-T | Biotium | 50U | EUR 159.6 |
|
Description: Minimum order quantity: 1 unit of 50U |
|||
Phalloidin, CF532 |
|||
| 00051 | Biotium | 300U | EUR 530.4 |
|
Description: Minimum order quantity: 1 unit of 300U |
|||
Phalloidin, CF532 |
|||
| 00051-T | Biotium | 50U | EUR 159.6 |
|
Description: Minimum order quantity: 1 unit of 50U |
|||
Phalloidin, CF660C |
|||
| 00052 | Biotium | 300U | EUR 530.4 |
|
Description: Minimum order quantity: 1 unit of 300U |
|||
Phalloidin, CF660C |
|||
| 00052-T | Biotium | 50U | EUR 159.6 |
|
Description: Minimum order quantity: 1 unit of 50U |
|||
Phalloidin, CF680 |
|||
| 00053 | Biotium | 300U | EUR 559.2 |
|
Description: Minimum order quantity: 1 unit of 300U |
|||
Phalloidin, CF680 |
|||
| 00053-T | Biotium | 50U | EUR 176.4 |
|
Description: Minimum order quantity: 1 unit of 50U |
|||
Phalloidin, CF430 |
|||
| 00054 | Biotium | 300U | EUR 538.8 |
|
Description: Minimum order quantity: 1 unit of 300U |
|||
Phalloidin, CF430 |
|||
| 00054-T | Biotium | 50U | EUR 166.8 |
|
Description: Minimum order quantity: 1 unit of 50U |
|||
Phalloidin, CF440 |
|||
| 00055 | Biotium | 300U | EUR 538.8 |
|
Description: Minimum order quantity: 1 unit of 300U |
|||
Phalloidin, CF440 |
|||
| 00055-T | Biotium | 50U | EUR 166.8 |
|
Description: Minimum order quantity: 1 unit of 50U |
|||
Cholera Toxin Subunit B, CF488A conjugate |
|||
| 00070 | Biotium | 100ug | EUR 313.2 |
|
Description: Minimum order quantity: 1 unit of 100ug |
|||
Cholera Toxin Subunit B, CF568 conjugate |
|||
| 00071 | Biotium | 100ug | EUR 313.2 |
|
Description: Minimum order quantity: 1 unit of 100ug |
|||
Cholera Toxin Subunit B, CF594 conjugate |
|||
| 00072 | Biotium | 100ug | EUR 313.2 |
|
Description: Minimum order quantity: 1 unit of 100ug |
|||
Cholera Toxin Subunit B, CF640R conjugate |
|||
| 00073 | Biotium | 100ug | EUR 316.8 |
|
Description: Minimum order quantity: 1 unit of 100ug |
|||
Cholera Toxin Subunit B, CF532 conjugate |
|||
| 00074 | Biotium | 100ug | EUR 316.8 |
|
Description: Minimum order quantity: 1 unit of 100ug |
|||
Cholera Toxin Subunit B, CF543 conjugate |
|||
| 00075 | Biotium | 100ug | EUR 316.8 |
|
Description: Minimum order quantity: 1 unit of 100ug |
|||
Cholera Toxin Subunit B, CF620R conjugate |
|||
| 00076 | Biotium | 100ug | EUR 316.8 |
|
Description: Minimum order quantity: 1 unit of 100ug |
|||
Cholera Toxin Subunit B, CF633 conjugate |
|||
| 00077 | Biotium | 100ug | EUR 316.8 |
|
Description: Minimum order quantity: 1 unit of 100ug |
|||
Cholera Toxin Subunit B, CF660R conjugate |
|||
| 00078 | Biotium | 100ug | EUR 316.8 |
|
Description: Minimum order quantity: 1 unit of 100ug |
|||
Cholera Toxin Subunit B, CF680R conjugate |
|||
| 00079 | Biotium | 100ug | EUR 338.4 |
|
Description: Minimum order quantity: 1 unit of 100ug |
|||
Human Transferrin, CF488A conjugate |
|||
| 00081 | Biotium | 1mg | EUR 178.8 |
|
Description: Minimum order quantity: 1 unit of 1mg |
|||
Human Transferrin, CF543 conjugate |
|||
| 00082 | Biotium | 1mg | EUR 178.8 |
|
Description: Minimum order quantity: 1 unit of 1mg |
|||
Human Transferrin, CF568 conjugate |
|||
| 00083 | Biotium | 1mg | EUR 178.8 |
|
Description: Minimum order quantity: 1 unit of 1mg |
|||
Human Transferrin, CF594 conjugate |
|||
| 00084 | Biotium | 1mg | EUR 178.8 |
|
Description: Minimum order quantity: 1 unit of 1mg |
|||
Human Transferrin, CF640R conjugate |
|||
| 00085 | Biotium | 1mg | EUR 178.8 |
|
Description: Minimum order quantity: 1 unit of 1mg |
|||
Human Transferrin, CF680R conjugate |
|||
| 00086 | Biotium | 1mg | EUR 178.8 |
|
Description: Minimum order quantity: 1 unit of 1mg |
|||
Human Transferrin, CF750 conjugate |
|||
| 00087 | Biotium | 1mg | EUR 186 |
|
Description: Minimum order quantity: 1 unit of 1mg |
|||
HIV-1 tat recombinant antigen |
|||
| 00110-V-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HIV-1 tat recombinant antigen full length 15 kDa |
|||
HIV-1 tat recombinant antigen |
|||
| 00110-V-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HIV-1 tat recombinant antigen full length 15 kDa |
|||
HIV-1 GAG P24 Recombinant Antigen |
|||
| 00111-V-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa |
|||
HIV-1 GAG P24 Recombinant Antigen |
|||
| 00111-V-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa |
|||
HIV-1 nef recombinant antigen |
|||
| 00112-V-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa |
|||
HIV-1 nef recombinant antigen |
|||
| 00112-V-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa |
|||
HIV-1 env gp41 recombinant antigen |
|||
| 00113-V-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa |
|||
HIV-1 env gp41 recombinant antigen |
|||
| 00113-V-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa |
|||
HIV-2 GP 36 Recombinant Antigen |
|||
| 00114-V-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa |
|||
HIV-2 GP 36 Recombinant Antigen |
|||
| 00114-V-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa |
|||
HCV core recombinant antigen |
|||
| 00115-V-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa |
|||
HCV core recombinant antigen |
|||
| 00115-V-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa |
|||
HCV core recombinant antigen, Biotin conjugate |
|||
| 00115-V-B-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate. |
|||
HCV core recombinant antigen, Biotin conjugate |
|||
| 00115-V-B-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate. |
|||
HCV core recombinant antigen, FITC conjugate |
|||
| 00115-V-F-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate. |
|||
HCV core recombinant antigen, FITC conjugate |
|||
| 00115-V-F-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate. |
|||
HCV core recombinant antigen, Rhodamine |
|||
| 00115-V-R-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate. |
|||
HCV core recombinant antigen, Rhodamine |
|||
| 00115-V-R-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate. |
|||
HCV NS4 recombinant antigen NS4a+b |
|||
| 00116-V-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. |
|||
HCV NS4 recombinant antigen NS4a+b |
|||
| 00116-V-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. |
|||
HCV NS4 recombinant antigen NS4a+b, Biotin |
|||
| 00116-V-B-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Biotin conjugate. |
|||
HCV NS4 recombinant antigen NS4a+b, Biotin |
|||
| 00116-V-B-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Biotin conjugate. |
|||
HCV NS4 recombinant antigen NS4a+b, FITC |
|||
| 00116-V-F-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Fluorescein conjugate. |
|||
HCV NS4 recombinant antigen NS4a+b, FITC |
|||
| 00116-V-F-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Fluorescein conjugate. |
|||
HCV NS4 recombinant antigen NS4a+b, Rhodamine |
|||
| 00116-V-R-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Rhodamine conjugate. |
|||
HCV NS4 recombinant antigen NS4a+b, Rhodamine |
|||
| 00116-V-R-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Rhodamine conjugate. |
|||
HCV NS3 recombinant antigen |
|||
| 00117-V-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HCV NS3 recombinant antigen a.a 1400 to a.a 1643 of HCV polyprotein 22 kDa |
|||
HCV NS3 recombinant antigen |
|||
| 00117-V-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HCV NS3 recombinant antigen a.a 1400 to a.a 1643 of HCV polyprotein 22 kDa |
|||
HBV core recombinant antigen |
|||
| 00120-V-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 183 of HBV core antigen 18 kDa |
|||
HBV core recombinant antigen |
|||
| 00120-V-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 183 of HBV core antigen 18 kDa |
|||
HBV core recombinant antigen, Delta |
|||
| 00121-V-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 144 of HBV core antigen 16 kDa |
|||
HBV core recombinant antigen, Delta |
|||
| 00121-V-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 144 of HBV core antigen 16 kDa |
|||
HBV surface recombinant antigen HBsAg |
|||
| 00122-V-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant |
|||
HBV surface recombinant antigen HBsAg |
|||
| 00122-V-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant |
|||
HBV surface recombinant antigen HBsAg antigen |
|||
| 00123-V-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant High purity |
|||
HBV surface recombinant antigen HBsAg antigen |
|||
| 00123-V-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant High purity |
|||
HBV surface recombinant antigen HBsAg antigen |
|||
| 00124-V-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HBV surface recombinant antigen HBsAg antigen 31 kDa E. coli recombinant |
|||
HBV surface recombinant antigen HBsAg antigen |
|||
| 00124-V-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HBV surface recombinant antigen HBsAg antigen 31 kDa E. coli recombinant |
|||
HEV (Birma) ORF2 recombinant antigen |
|||
| 00131-V-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HEV (Birma) ORF2 recombinant antigen a.a. 633 to a.a 659. |
|||
HEV (Birma) ORF2 recombinant antigen |
|||
| 00131-V-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HEV (Birma) ORF2 recombinant antigen a.a. 633 to a.a 659. |
|||
HEV (Birma) ORF2 recombinant antigen |
|||
| 00132-V-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HEV (Birma) ORF2 recombinant antigen a.a. 403 to a.a 461. |
|||
HEV (Birma) ORF2 recombinant antigen |
|||
| 00132-V-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HEV (Birma) ORF2 recombinant antigen a.a. 403 to a.a 461. |
|||
AA 403-461 HEV Birma ORF2 Recombinant Antigen |
|||
| 00133-V-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HEV (Birma) ORF2 recombinant antigen a.a. 92 to a.a 123. |
|||
AA 403-461 HEV Birma ORF2 Recombinant Antigen |
|||
| 00133-V-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HEV (Birma) ORF2 recombinant antigen a.a. 92 to a.a 123. |
|||
T, Pallidum recombinant antigen p15 |
|||
| 00141-V-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: T. Pallidum recombinant antigen p15 (full length) |
|||
T, Pallidum recombinant antigen p15 |
|||
| 00141-V-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: T. Pallidum recombinant antigen p15 (full length) |
|||
T, Pallidum recombinant antigen p17 |
|||
| 00142-V-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: T. Pallidum recombinant antigen p17 (full length) |
|||
T, Pallidum recombinant antigen p17 |
|||
| 00142-V-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: T. Pallidum recombinant antigen p17 (full length) |
|||
T, Pallidum recombinant antigen p45 |
|||
| 00143-V-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: T. Pallidum recombinant antigen p45 (full length) |
|||
T, Pallidum recombinant antigen p45 |
|||
| 00143-V-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: T. Pallidum recombinant antigen p45 (full length) |
|||
T, pallidum recombinant antigen TmpA |
|||
| 00144-V-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: T. Pallidum recombinant antigen TmpA (full length) |
|||
T, pallidum recombinant antigen TmpA |
|||
| 00144-V-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: T. Pallidum recombinant antigen TmpA (full length) |
|||
HCV core 2-119aa recombinant antigen |
|||
| 00150-V-01mg | Virogen | 0,1 mg | EUR 321 |
|
Description: HCV core 2-119aa recombinant antigen. Genotypes available: 1a, 1b, 2a, 2b, 3a, 3b, 3/10, 4, 5, 6a |
|||
HCV core 2-119aa recombinant antigen |
|||
| 00150-V-1000ug | Virogen | 1000 ug | EUR 1539 |
|
Description: HCV core 2-119aa recombinant antigen. Genotypes available: 1a, 1b, 2a, 2b, 3a, 3b, 3/10, 4, 5, 6a |
|||
MiR-96-5p expression was upregulated by SDC-4-specific antibodies in chondrocytes and cartilage tissue, and miR-96-5p instantly focused the three’-UTR of HIF-2α to inhibit HIF-2α signaling in murine chondrocytes. Furthermore, we demonstrated that anti-SDC-4-attenuated IL-1β-induced chondrocyte hypertrophy and cartilage degradation by inhibiting HIF-2α signaling by a miR-96-5p-dependent mechanism. Our examine revealed that the inhibition of SDC-Four exerts its results on each cartilage homeostasis and the chondrocyte hypertrophy phenotype by inducing miR-96-5p expression, which leads to focusing on HIF-2α 3′-UTR sequences and inhibiting HIF-2α in murine cartilage tissue and chondrocytes.