Clear cell renal cell carcinoma (ccRCC) has been the most typical renal cell carcinoma (RCC). Though the illness classification, prognosis and focused remedy of RCC has been more and more evolving attributing to the fast growth of present molecular pathology, the present scientific therapy state of affairs continues to be difficult contemplating the great and progressively growing nature of malignant most cancers. The examine is to establish extra potential accountable genes throughout the growth of ccRCC utilizing bioinformatic evaluation, thus aiding extra exact interpretation of the illness
Firstly, totally different cDNA expression profiles from Gene Expression Omnibus (GEO) on-line database have been used to display the irregular in another way expressed genes (DEGs) between ccRCC and regular renal tissues. Then, primarily based on the protein-protein interplay community (PPI) of all DEGs, the module evaluation was carried out to scale down the potential genes, and additional survival evaluation assisted our continuing to the subsequent step for choosing a reputable key gene. Lastly, the potential organic perform of the gene and signaling mechanism of gene regulating ccRCC growth was preliminary explored.
4 cDNA expression profiles have been picked from GEO database primarily based on the variety of containing pattern circumstances, and a complete of 192 DEGs, together with 39 up-regulated and 153 down-regulated genes have been shared in 4 profiles. Based mostly on the DEGs PPI community, 4 perform modules have been recognized highlighting a FGF1 gene involving PI3K-AKT signaling pathway which was shared in 3/Four modules. Additional, each the IHC carried out with ccRCC tissue microarray which contained 104 native samples and QPCR performed utilizing 30 totally different samples confirmed that FGF1 was aberrant misplaced in ccRCC.
And Kaplan-Meier total survival evaluation revealed that FGF1 gene loss was associated to worse ccRCC sufferers survival. Lastly, the pathological scientific options of FGF1 gene and the possible organic capabilities and signaling pathways it concerned have been analyzed utilizing TCGA scientific information. Utilizing bioinformatic evaluation, we revealed that FGF1 expression was aberrant misplaced in ccRCC which statistical considerably correlated with sufferers total survival, and the gene’s scientific options and potential organic capabilities have been additionally explored. Nonetheless, extra detailed experiments and scientific trials are wanted to help its potential drug-target function in scientific medical use.
microR-4449 Promotes Colorectal Most cancers Cell Proliferation through Regulation of SOCS3 and Activation of STAT3 Signaling
The microarray information of GSE115513 have been retrieved; subsequently, the differentially expressed miRNAs between 411 colon tumors and 381 regular colon mucosa have been analyzed. Actual-time PCR (RT-qPCR) and bioinformatic evaluation have been utilized to look at the expression of miR-4449 in collected colorectal tumors and printed microarray information. The exercise of sign transducer and activator of transcription 3 (STAT3) signaling was detected by Western blotting and RT-qPCR. Twin-Luciferase assay and bioinformatic evaluation have been used to verify the interplay between suppressor of cytokine signaling 3 (SOCS3) and miR-4449.
Lack of perform and rescue assays have been carried out to review the involvement of miR-4449 and SOCS3 in cell proliferation and apoptosis of colorectal most cancers. Herein, we recognized miR-4449 as a novel upregulated miRNA in colorectal most cancers. Our information advised that miR-4449 downregulation blocked the proliferation of colorectal most cancers cells accompanied with the elevation of cell apoptosis. Thirdly, immunohistochemistry (IHC) and quantitative real-time PCR (QPCR) have been performed to validate the expression change of the important thing gene in ccRCC evaluating to regular tissues, in the meantime the prognostic worth was verified utilizing TCGA scientific information.
Decreased expression of miR-4449 led to inactivation of STAT3 pathway as indicated by dephosphorylation of STAT3 and downregulation of STAT3 goal genes, together with vascular endothelial development issue (VEGF), c-Myc, baculovirus inhibitor of apoptosis containing 5 (BIRC5). Moreover, SOCS3, a detrimental regulator of STAT3 pathway, was discovered to be a goal gene of miR-4449. The info additionally confirmed that the inactivation of STAT3 pathway by miR-4449 inhibitor was realized by focusing on SOCS3. Furthermore, the organic perform of miR-4449 downregulation was reversed by SOCS3 knockdown in colorectal most cancers cells.
Inhibition of syndecan-Four reduces cartilage degradation in murine fashions of osteoarthritis by way of the downregulation of HIF-2α by miR-96-5p
The membranous receptor syndecan-4 (SDC-4) and the nuclear transcription issue hypoxia-induced factor-2α (HIF-2α) play vital roles within the pathogenesis of osteoarthritis (OA). The purpose of this examine was to find out whether or not SDC-Four inhibition downregulates HIF-2a expression by microRNA-96-5p (miR-96-5p) in murine chondrocyte and cartilage tissue. The OA mannequin was induced surgically in mice, and SDC-Four polyclonal antibody, HIF-2α small interfering RNA (siRNA) and its management, miR-96-5p mimics and its scrambled controls or anti-miR-96-5p and its management have been then injected into the knee joints.
At 2 and Four weeks after surgical procedure, OA development was evaluated microscopically, histologically, radiographically and immunohistochemically in these mice. Actual-time polymerase chain response (RT-PCR) and western blotting have been carried out after treating with antibody and transfecting with miRNA mimic or siRNA to find out their results on OA-related mediators. The potential miRNAs associated to OA growth have been recognized through the use of miRNA microarray evaluation. Whether or not miRNAs play a pivotal function in OA growth in vivo or in vitro was additionally investigated.
 19 mm Diameter Tapped Titanium Tip |
|
0-120-0012 |
Biologics |
19 mm |
EUR 639 |
 19 mm Diameter Solid Titanium Tip |
|
0-120-0013 |
Biologics |
19 mm |
EUR 570 |
 25 mm Diameter Tapped Titanium Tip |
|
0-120-0014 |
Biologics |
25 mm |
EUR 682 |
 25 mm Diameter Solid Titanium Tip |
|
0-120-0015 |
Biologics |
25 mm |
EUR 614 |
 Flat Replaceable Tips 13 mm Diameter Flat Titanium Tip |
|
0-120-0016 |
Biologics |
13 mm |
EUR 86 |
|
Description: use with corresponding Tapped Tips and Tapped Extender Tips |
 Flat Replaceable Tips 19 mm Diameter Flat Titanium Tip |
|
0-120-0017 |
Biologics |
19 mm |
EUR 92 |
|
Description: use with corresponding Tapped Tips and Tapped Extender Tips |
 Flat Replaceable Tips 25 mm Diameter Flat Titanium Tip |
|
0-120-0018 |
Biologics |
25 mm |
EUR 100 |
|
Description: use with corresponding Tapped Tips and Tapped Extender Tips |
 Titanium Cup Tip, 250 ml |
|
0-120-0019 |
Biologics |
250 ml |
EUR 1377 |
|
Description: includes Interface Washers |
) Microtube Tray, 8 Position (for 250 ml Cup Tip) |
|
0-120-0021 |
Biologics |
each |
EUR 113 |
|
Description: includes Interface Washers |
 Continuous Flow Chamber |
|
0-120-0026 |
Biologics |
each |
EUR 774 |
|
Description: includes Interface Washers |
 Interface Washers 1.5” Diameter, 5/Pkg |
|
0-120-003 |
Biologics |
1.5'' Diameter |
EUR 31 |
 13 mm Diameter Solid Titanium Extender Tip |
|
0-120-0032 |
Biologics |
13 mm |
EUR 301 |
 13 mm Diameter Tapped Titanium Extender Tip |
|
0-120-0033 |
Biologics |
13 mm |
EUR 362 |
 19 mm Diameter Solid Titanium Extender Tip |
|
0-120-0034 |
Biologics |
19 mm |
EUR 315 |
 19 mm Diameter Tapped Titanium Extender Tip |
|
0-120-0035 |
Biologics |
19 mm |
EUR 375 |
 25 mm Diameter Solid Titanium Extender Tip |
|
0-120-0036 |
Biologics |
25 mm |
EUR 328 |
 25 mm Diameter Tapped Titanium Extender Tip |
|
0-120-0037 |
Biologics |
25 mm |
EUR 389 |
 KoldPod, 1.5ml Micro Tube |
|
0-120-0038 |
Biologics |
1.5 ml |
EUR 152 |
|
Description: Thermo conductive tube pods |
 KoldPod, 15ml Conical Tube |
|
0-120-0039 |
Biologics |
15 ml |
EUR 275 |
|
Description: Thermo conductive tube pods |
 KoldPod, 50ml Conical Tube |
|
0-120-0040 |
Biologics |
50 ml |
EUR 290 |
|
Description: Thermo conductive tube pods |
 Model 150 V/T Ultrasonic Homogenizer |
|
0-121-0002 |
Biologics |
210-240V/50-60Hz |
EUR 2920 |
|
|
|
Description: Delivers up to 150 Watts of ultrasonic power to the Titanium Tip. The Timer and Duty Cycle function increase preciosion in sample processing processing. |
 Model 300 V/T Ultrasonic Homogenizer |
|
0-122-0002 |
Biologics |
210-240V/50-60Hz |
EUR 3520 |
|
|
|
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip. The Timer and Duty Cycle function increase preciosion in sample. |
 SONABOZ Sound Abating Chamber |
|
0-125-0001 |
Biologics |
each |
EUR 1020 |
|
Description: Reduces cavitational sound emitted during processing. |
 Model 3000 Ultrasonic Homogenizer |
|
0-127-0002 |
Biologics |
210-240V/50-60Hz |
EUR 4120 |
|
|
|
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip and includes an intergrated Sound Abating Chmaber to reduce cavitational sound emitted during processing. The Timer and Duty Cycle function increase preciosion in sample. |
 Model 3000MP Ultrasonic Homogenizer |
|
0-128-0002 |
Biologics |
210-240V/50-60Hz |
EUR 4720 |
|
|
|
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip with preciosion control from a microprocessor and a graphical user interface displayed on a large (145 mm) LCD display. The integrated Sound Abating Chamber reduces cavitational sound emitted during processing. |
 OMNICON® Zone Reader, 210-240V/50-60Hz |
|
0-131-0002 |
Biologics |
210-240V/50-60Hz |
EUR 35200 |
|
|
|
Description: Designed to Perform multi-plate Assays on round 90/100mm Petri Dishes. The integrated LED illumination system provides transmitted light for brightfield and darkfield illumination of transparent media. |
 OMNI-Noculator Peni Cylinder Filler, 210-240V/50-60Hz |
|
0-134-0002 |
Biologics |
210-240V/50-60Hz |
EUR 32200 |
|
|
|
Description: A robotic liquid handling system designed to dispense Peni Cylinders and fill Peni Cylinders with the corresponding antibiotic liquid sample. |
 Peni Cylinder Dispenser with Manual Hopper |
|
0-144-0002 |
Biologics |
each |
EUR 5406 |
|
|
|
Description: Dispenser can be configured to dispense 4 or 6 Peni Cylinders onto a petri dish. |
 Peni Cylinder Dispenser with Motorized Hopper, 100-240V/50-60Hz |
|
0-144-0003 |
Biologics |
100-240V/50-60Hz |
EUR 6254 |
|
Description: The motorized hopper can be configured to dispense 4 or 6 Peni Cylinders onto a petri Dispenser can be disassembled for disinfection. |
 Stainless Steel Peni Cylinder with Flat Face |
|
0-144-0005 |
Biologics |
6mm I.D. x 8mm O.D. x 10mm Long |
EUR 399 |
|
Description: sold in packages of 100 pieces |
 Stainless Steel Peni Cylinder with Chamfered Face |
|
0-144-0006 |
Biologics |
6mm I.D. x 8mm O.D. x 10mm Long |
EUR 412 |
|
Description: sold in packages of 100 pieces |
) Custom development of ELISAs for other species or antibody isotypes not listed in the catalog. Custom testing of samples for IgG/IgM/IgA or total (IgG+IgM+IgA) |
|
000-CUS |
Alpha Diagnostics |
Custom |
EUR 602 |
 Alpha-Bungarotoxin, CF®405S, 500 ug |
|
00002 |
Biotium |
1UG |
EUR 527 |
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
 Alpha-bungarotoxin, CF405s |
|
00002 |
Cusabio |
500uG |
EUR 594 |
|
Description: Minimum order quantity: 1 unit of 500uG |
Alpha-Bungarotoxin, CF®405S, 500 ug |
|
00002-1 |
Biotium |
EA |
EUR 527 |
 Alpha-Bungarotoxin, CF®405S 100ug |
|
00002-100ug |
Biotium |
100uG |
EUR 132 |
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
 Alpha-Bungarotoxin, CF®680R, 500 ug |
|
9-00003 |
Biotium |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®680R, 500 ug |
|
00003-1 |
Biotium |
EA |
EUR 527 |
 Alpha-Bungarotoxin, CF®680R 100ug |
|
9-00003 |
Biotium |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
 Alpha-Bungarotoxin, CF®640R, 500 ug |
|
9-00004 |
Biotium |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®640R, 500 ug |
|
00004-1 |
Biotium |
EA |
EUR 527 |
 Alpha-Bungarotoxin, CF®640R 100ug |
|
9-00004 |
Biotium |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
 Alpha-Bungarotoxin, CF®488A, 500 ug |
|
9-00005 |
Biotium |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®488A, 500 ug |
|
00005-1 |
Biotium |
EA |
EUR 527 |
 Alpha-Bungarotoxin CF®488A 100ug |
|
9-00005 |
Biotium |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
 Alpha-Bungarotoxin, CF®568, 500 ug |
|
9-00006 |
Biotium |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®568, 500 ug |
|
00006-1 |
Biotium |
EA |
EUR 527 |
 Alpha-Bungarotoxin, CF®568 100ug |
|
9-00006 |
Biotium |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
 Alpha-Bungarotoxin, CF®594, 500 ug |
|
9-00007 |
Biotium |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®594, 500 ug |
|
00007-1 |
Biotium |
EA |
EUR 527 |
 Alpha-Bungarotoxin CF®594 100ug |
|
9-00007 |
Biotium |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
 Alpha-Bungarotoxin, CF®633, 500 ug |
|
9-00009 |
Biotium |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®633, 500 ug |
|
00009-1 |
Biotium |
EA |
EUR 527 |
 Alpha-Bungarotoxin, CF®633 100ug |
|
9-00009 |
Biotium |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
 SARS-CoV-2 Indicator Cell Line for RNA Replication - GFP Reporter only |
|
0001-PP-001 |
IBT Bioservices |
1 cell line (can order x amount) |
EUR 12000 |
|
Description: SARS-CoV-2 GFP reporter cell line using HEK293T (ACE2/TMPRSS2) cells |
 Alpha-Bungarotoxin, 1 mg |
|
00010-1 |
Biotium |
1MG |
EUR 193 |
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, 1 mg |
|
00010-1-1 |
Biotium |
EA |
EUR 193 |
 Fluorescein-Alpha-Bungarotoxin, 500 ug |
|
00011 |
Biotium |
500uG |
EUR 376 |
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Fluorescein-Alpha-Bungarotoxin, 500 ug |
|
00011-1 |
Biotium |
EA |
EUR 376 |
 Tetramethylrhodamine-Alpha-Bungarotoxin, 500 ug |
|
00012 |
Biotium |
500uG |
EUR 394 |
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Tetramethylrhodamine-Alpha-Bungarotoxin, 500 ug |
|
00012-1 |
Biotium |
EA |
EUR 394 |
 Fluorescein-alpha-bungarotoxin, 10x50ug |
|
00013 |
Biotium |
10ST |
EUR 436 |
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Fluorescein-alpha-bungarotoxin, 10x50ug |
|
00013-1 |
Biotium |
EA |
EUR 436 |
 Tetramethylrhodamine-A-Bungarotoxin, 10x50 ug |
|
00014 |
Biotium |
10ST |
EUR 494 |
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Tetramethylrhodamine-A-Bungarotoxin, 10x50 ug |
|
00014-1 |
Biotium |
EA |
EUR 494 |
 Sulforhodamine 101-Alpha-Bungarotoxin, 500 ug |
|
00015 |
Biotium |
500uG |
EUR 494 |
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Sulforhodamine 101-Alpha-Bungarotoxin, 500 ug |
|
00015-1 |
Biotium |
EA |
EUR 494 |
 Sulforhodamine 101-Alpha-Bungarotoxin, 50 ug |
|
00016 |
Biotium |
10ST |
EUR 560 |
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Sulforhodamine 101-Alpha-Bungarotoxin, 50 ug |
|
00016-1 |
Biotium |
EA |
EUR 560 |
 Biotin-XX-A-Bungarotoxin, 500 ug |
|
00017 |
Biotium |
500uG |
EUR 455 |
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Biotin-XX-A-Bungarotoxin, 500 ug |
|
00017-1 |
Biotium |
EA |
EUR 455 |
 Alpha-Bungarotoxin, CF®555, 500 ug |
|
9-00018 |
Biotium |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®555, 500 ug |
|
00018-1 |
Biotium |
EA |
EUR 527 |
 Alpha-Bungarotoxin, CF®555 100ug |
|
9-00018 |
Biotium |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
 Biotin-cAMP, 1 mg |
|
00020 |
Biotium |
1MG |
EUR 298 |
|
|
|
Description: N/A |
Biotin-cAMP, 1 mg |
|
00020-1 |
Biotium |
20ST |
EUR 298 |
|
|
|
Description: N/A |
 Biotin-cAMP, 50 ug |
|
00020-1-1 |
Biotium |
EA |
EUR 414 |
 Biotin-cGMP, 1 mg |
|
00021 |
Biotium |
1MG |
EUR 331 |
|
|
|
Description: N/A |
Biotin-cGMP, 1 mg |
|
00021-1 |
Biotium |
20ST |
EUR 331 |
|
|
|
Description: N/A |
 Biotin-cGMP, 20x50 ug |
|
00021-1-1 |
Biotium |
EA |
EUR 447 |
 Cyanine 644-cAMP, 1 mg |
|
00022 |
Biotium |
1MG |
EUR 496 |
|
|
|
Description: N/A |
Cyanine 644-cAMP, 1 mg |
|
00022-1 |
Biotium |
20ST |
EUR 496 |
|
|
|
Description: N/A |
 Cyanine 644-cAMP, 20x50 ug |
|
00022-1-1 |
Biotium |
EA |
EUR 647 |
 Fluorescein Methotrexate, Triammonium Salt, 1 mg |
|
00023 |
Biotium |
1MG |
EUR 285 |
|
|
|
Description: N/A |
Fluorescein Methotrexate, Triammonium Salt, 1 mg |
|
00023-1 |
Biotium |
EA |
EUR 285 |
 Staurosporine |
|
00025 |
Biotium |
100uG |
EUR 100 |
|
|
|
Description: N/A |
Staurosporine |
|
00025-1 |
Biotium |
EA |
EUR 100 |
 Alpha-Bungarotoxin, CF®543, 500 ug |
|
00026 |
Biotium |
500uG |
EUR 527 |
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®543, 500 ug |
|
00026-1 |
Biotium |
EA |
EUR 527 |
 Alpha-Bungarotoxin, CF®543, 100 ug |
|
00026-100ug |
Biotium |
1UG |
EUR 132 |
|
|
|
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
 Rhodamine Phalloidin 300U |
|
00027 |
Biotium |
300 |
EUR 364 |
|
|
|
Description: N/A |
Rhodamine Phalloidin 300U |
|
00027-1 |
Biotium |
EA |
EUR 364 |
 Biotin-XX-Phalloidin |
|
00028 |
Biotium |
100U |
EUR 466 |
|
|
|
Description: N/A |
Biotin-XX-Phalloidin |
|
00028-1 |
Biotium |
EA |
EUR 466 |
 Fluorescein-Phalloidin |
|
00030 |
Biotium |
300U |
EUR 364 |
|
|
|
Description: N/A |
Fluorescein-Phalloidin |
|
00030-1 |
Biotium |
EA |
EUR 364 |
 Rhodamine 110 Phalloidin |
|
00032 |
Biotium |
300ST |
EUR 364 |
|
|
|
Description: N/A |
Rhodamine 110 Phalloidin |
|
00032-1 |
Biotium |
EA |
EUR 364 |
 Phalloidin) Sulforhodamine 101 (Texas Red®) Phalloidin |
|
00033 |
Biotium |
300EU |
EUR 364 |
|
|
|
Description: N/A |
Sulforhodamine 101 (Texas Red®) Phalloidin |
|
00033-1 |
Biotium |
EA |
EUR 364 |
 Phalloidin, CF®405M |
|
00034 |
Biotium |
300U |
EUR 482 |
|
|
|
Description: N/A |
Phalloidin, CF®405M |
|
00034-1 |
Biotium |
EA |
EUR 482 |
Phalloidin, CF®405M |
|
00034-T |
Biotium |
50U |
EUR 101 |
|
|
|
Description: N/A |
Phalloidin, CF®405M |
|
00034-T-1 |
Biotium |
EA |
EUR 101 |
 CF®488A-cAMP |
|
00036 |
Biotium |
100ug |
EUR 136 |
|
|
|
Description: N/A |
CF®488A-cAMP |
|
00036-1 |
Biotium |
EA |
EUR 136 |
 CF®640R-cAMP |
|
00037 |
Biotium |
100ug |
EUR 136 |
|
|
|
Description: N/A |
CF®640R-cAMP |
|
00037-1 |
Biotium |
EA |
EUR 136 |
 Phalloidin, CF555 |
|
00040 |
Biotium |
300U |
EUR 530.4 |
|
Description: Minimum order quantity: 1 unit of 300U |
Phalloidin, CF555 |
|
00040-T |
Biotium |
50U |
EUR 159.6 |
|
Description: Minimum order quantity: 1 unit of 50U |
 Phalloidin, CF®647, 300 U |
|
00041 |
Biotium |
300U |
EUR 482 |
|
|
|
Description: N/A |
Phalloidin, CF®647, 300 U |
|
00041-1 |
Biotium |
EA |
EUR 482 |
 Phalloidin, CF®647, 50 U |
|
00041-T |
Biotium |
50U |
EUR 101 |
|
|
|
Description: N/A |
Phalloidin, CF®647, 50 U |
|
00041-T-1 |
Biotium |
EA |
EUR 101 |
 Phalloidin, CF®488A, 300 U |
|
00042 |
Biotium |
300U |
EUR 482 |
|
|
|
Description: N/A |
Phalloidin, CF®488A, 300 U |
|
00042-1 |
Biotium |
EA |
EUR 482 |
 Phalloidin, CF®488A, 50 U |
|
00042-T |
Biotium |
50U |
EUR 101 |
|
|
|
Description: N/A |
Phalloidin, CF®488A, 50 U |
|
00042-T-1 |
Biotium |
EA |
EUR 101 |
 Phalloidin, CF®543, 300 U |
|
00043 |
Biotium |
300U |
EUR 482 |
|
|
|
Description: N/A |
Phalloidin, CF®543, 300 U |
|
00043-1 |
Biotium |
EA |
EUR 482 |
 Phalloidin, CF®543, 50 U |
|
00043-T |
Biotium |
50U |
EUR 101 |
|
|
|
Description: N/A |
Phalloidin, CF®543, 50 U |
|
00043-T-1 |
Biotium |
EA |
EUR 101 |
 Phalloidin, CF®568, 300 U |
|
00044 |
Biotium |
300U |
EUR 482 |
|
|
|
Description: N/A |
Phalloidin, CF®568, 300 U |
|
00044-1 |
Biotium |
EA |
EUR 482 |
 Phalloidin, CF®568, 50 U |
|
00044-T |
Biotium |
50U |
EUR 101 |
|
|
|
Description: N/A |
Phalloidin, CF®568, 50 U |
|
00044-T-1 |
Biotium |
EA |
EUR 101 |
 Phalloidin, CF®594, 300 U |
|
00045 |
Biotium |
300U |
EUR 482 |
|
|
|
Description: N/A |
Phalloidin, CF®594, 300 U |
|
00045-1 |
Biotium |
EA |
EUR 482 |
 Phalloidin, CF®594, 50 U |
|
00045-T |
Biotium |
50U |
EUR 101 |
|
|
|
Description: N/A |
Phalloidin, CF®594, 50 U |
|
00045-T-1 |
Biotium |
EA |
EUR 101 |
 Phalloidin, CF®633, 300 U |
|
00046 |
Biotium |
300U |
EUR 482 |
|
|
|
Description: N/A |
Phalloidin, CF®633, 300 U |
|
00046-1 |
Biotium |
EA |
EUR 482 |
 Phalloidin, CF®633, 50 U |
|
00046-T |
Biotium |
50U |
EUR 101 |
|
|
|
Description: N/A |
Phalloidin, CF®633, 50 U |
|
00046-T-1 |
Biotium |
EA |
EUR 101 |
 Phalloidin, CF®660R, 300 U |
|
00047 |
Biotium |
300U |
EUR 482 |
|
|
|
Description: N/A |
Phalloidin, CF®660R, 300 U |
|
00047-1 |
Biotium |
EA |
EUR 482 |
 Phalloidin, CF®660R, 50 U |
|
00047-T |
Biotium |
50U |
EUR 101 |
|
|
|
Description: N/A |
Phalloidin, CF®660R, 50 U |
|
00047-T-1 |
Biotium |
EA |
EUR 101 |
 Phalloidin, CF®680R, 300 U |
|
00048 |
Biotium |
300U |
EUR 513 |
|
|
|
Description: N/A |
Phalloidin, CF®680R, 300 U |
|
00048-1 |
Biotium |
EA |
EUR 513 |
MiR-96-5p expression was upregulated by SDC-4-specific antibodies in chondrocytes and cartilage tissue, and miR-96-5p instantly focused the three’-UTR of HIF-2α to inhibit HIF-2α signaling in murine chondrocytes. Furthermore, we demonstrated that anti-SDC-4-attenuated IL-1β-induced chondrocyte hypertrophy and cartilage degradation by inhibiting HIF-2α signaling by a miR-96-5p-dependent mechanism. Our examine revealed that the inhibition of SDC-Four exerts its results on each cartilage homeostasis and the chondrocyte hypertrophy phenotype by inducing miR-96-5p expression, which leads to focusing on HIF-2α 3′-UTR sequences and inhibiting HIF-2α in murine cartilage tissue and chondrocytes.
