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Progesterone suppresses the progression of colonic carcinoma by increasing the activity of the GADD45α/JNK/c‑Jun signalling pathway

Progesterone suppresses the progression of colonic carcinoma by increasing the activity of the GADD45α/JNK/c‑Jun signalling pathway

Posted on May 13, 2021April 23, 2021 by Vawter

Colorectal most cancers (CRC) is the third most identified most cancers worldwide. Progesterone is related to a decreased danger of CRC and results in a beneficial prognosis. Nonetheless, the precise mechanism by which progesterone suppresses malignant development stays to be elucidated. Within the current research, the extent of progesterone was first analysed in 77 sufferers with CRC, and immunohistochemistry was carried out to detect the expression of progesterone receptor (PGR) within the paired specimens. The correlations between progesterone, PGR and CRC prognosis had been assessed. A Cell Counting Package‑eight assay was then used to detect proliferation of the CRC cells. Circulation cytometry was carried out to estimate apoptosis and to guage the cycle of the CRC cells.

A xenograft tumour mannequin was established in nude mice to evaluate the function of progesterone in tumour development. Lastly, a PCR microarray was used to display screen differentially expressed genes to additional interpret the mechanism by which progesterone inhibits the malignant development of CRC. It was discovered that low expression of progesterone and PGR had been considerably related to poor prognosis of CRC. As well as, progesterone suppressed CRC cell proliferation by arresting the cell cycle and inducing apoptosis in vitro. Furthermore, the inhibitory function of progesterone in tumour development was verified in vivo.

Additional investigation confirmed that the extent of development arrest and DNA harm‑inducible protein α (GADD45α) was up‑regulated by progesterone, and this was adopted by the activation of the JNK pathway. Progesterone elevated the exercise of the JNK pathway through GADD45α to inhibit proliferation by arresting the cell cycle and inducing apoptosis, thereby suppressing the malignant development of CRC. Subsequently, it may be concluded that progesterone and PGR may act as inhibiting elements for poor prognosis of CRC.

Decide the incremental yield of subsequent technology sequencing (predominantly exome sequencing (ES)) over quantitative fluorescence-polymerase chain response (QF-PCR) and chromosome microarray evaluation (CMA)/karyotyping in; (i) all instances of prenatally identified non-immune hydrops fetalis (NIHF); (ii) remoted NIHF; (iii) NIHF related to further structural anomalies and; (iv) NIHF in line with severity (i.e., two cavities versus three or extra cavities affected).

MiRNA expression profiling and emergence of latest prognostic signature for oral squamous cell carcinoma

Oral squamous cell carcinoma (OSCC), the commonest sort of head and neck cancers, is related to excessive recurrence, metastasis, low long-term survival charges and poor remedy consequence. As deregulated miRNA expression performs an important function in malignant transformation and most cancers development, the current research is aimed toward profiling the miRNA expression sample in OSCC and creating a brand new miRNA prognostic signature for oral most cancers. MiRNA expression profiling was carried out utilizing MiRNA microarray in 30 tumor and 18 regular samples. MiRNA signature obtained was validated with quantitative actual time PCR (qRT-PCR) in 144 tumor and 36 regular samples.

The potential targets, scientific implications and prognostic worth of the miRNA signature had been elucidated by numerous bioinformatics and statistical analyses. Microarray profiling recognized a set of 105 miRNAs to be differentially expressed in OSCC, out of which a subset of 19 most dysregulated miRNAs had been validated by qRT-PCR. In silico evaluation revealed the signature miRNAs to be concerned in numerous most cancers related pathways. Up-regulation of miR-196a, miR-21, miR-1237 and downregulation of miR-204, miR-144 was related to poor prognosis of OSCC sufferers. The mir-196a/miR-204 expression ratio emerged as finest predictor for illness recurrence and affected person survival. Altogether, our research recognized a miRNA signature for OSCC with prognostic significance.

Progesterone suppresses the progression of colonic carcinoma by increasing the activity of the GADD45α/JNK/c‑Jun signalling pathway

Identification of fibroblast activation-related genes in two acute kidney harm fashions

Ischemia-reperfusion harm and drug-induced nephrotoxicity are the 2 most typical causes for acute kidney harm (AKI). Nonetheless, little consideration has been paid to early activation of fibroblasts within the development of AKI to persistent kidney illness (CKD). The current research aimed to determine associated genes and pathways on fibroblast activation in two mouse fashions of AKI: ischemia-reperfusion harm (IRI) mannequin and folic acid (FA)-induced harm mannequin. The microarray expression profiles of GSE62732 and GSE121190 had been downloaded from the GEO database, and the differentially expressed genes (DEGs) was analyzed utilizing the Limma bundle of R software program.

Principal element evaluation (PCA) was additionally carried out utilizing R. The practical info of gene merchandise was annotated by Gene Ontology (GO) and DAVID on-line database, and the pathway evaluation was carried out through the use of the Kyoto Encyclopedia of Genes and Genomes pathway (KEGG) database. Protein-protein interactions (PPI) community was constructed by STRING and Cytoscape. Moreover, within the Hypoxia/Reoxygenation (H/R) mannequin, the morphological adjustments of cells had been noticed beneath microscope and the expression of the hub genes in NRK-49F cells had been validated by qRT-PCR assays. A complete of 457 DEGs had been recognized.

25 mm Diameter Tapped Titanium Tip

0-120-0014 Biologics 25 mm
EUR 682

25 mm Diameter Solid Titanium Tip

0-120-0015 Biologics 25 mm
EUR 614

Flat Replaceable Tips 13 mm Diameter Flat Titanium Tip

0-120-0016 Biologics 13 mm
EUR 86
Description: use with corresponding Tapped Tips and Tapped Extender Tips

Flat Replaceable Tips 19 mm Diameter Flat Titanium Tip

0-120-0017 Biologics 19 mm
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Flat Replaceable Tips 25 mm Diameter Flat Titanium Tip

0-120-0018 Biologics 25 mm
EUR 100
Description: use with corresponding Tapped Tips and Tapped Extender Tips

Titanium Cup Tip, 250 ml

0-120-0019 Biologics 250 ml
EUR 1377
Description: includes Interface Washers

Microtube Tray, 8 Position (for 250 ml Cup Tip)

0-120-0021 Biologics each
EUR 113
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Continuous Flow Chamber

0-120-0026 Biologics each
EUR 774
Description: includes Interface Washers

Interface Washers 1.5” Diameter, 5/Pkg

0-120-003 Biologics 1.5'' Diameter
EUR 31

13 mm Diameter Solid Titanium Extender Tip

0-120-0032 Biologics 13 mm
EUR 301

13 mm Diameter Tapped Titanium Extender Tip

0-120-0033 Biologics 13 mm
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19 mm Diameter Solid Titanium Extender Tip

0-120-0034 Biologics 19 mm
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19 mm Diameter Tapped Titanium Extender Tip

0-120-0035 Biologics 19 mm
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25 mm Diameter Solid Titanium Extender Tip

0-120-0036 Biologics 25 mm
EUR 328

25 mm Diameter Tapped Titanium Extender Tip

0-120-0037 Biologics 25 mm
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KoldPod, 1.5ml Micro Tube

0-120-0038 Biologics 1.5 ml
EUR 152
Description: Thermo conductive tube pods

KoldPod, 15ml Conical Tube

0-120-0039 Biologics 15 ml
EUR 275
Description: Thermo conductive tube pods

KoldPod, 50ml Conical Tube

0-120-0040 Biologics 50 ml
EUR 290
Description: Thermo conductive tube pods

Model 150 V/T Ultrasonic Homogenizer

0-121-0002 Biologics 210-240V/50-60Hz
EUR 2920
Description: Delivers up to 150 Watts of ultrasonic power to the Titanium Tip. The Timer and Duty Cycle function increase preciosion in sample processing processing.

Model 300 V/T Ultrasonic Homogenizer

0-122-0002 Biologics 210-240V/50-60Hz
EUR 3520
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip. The Timer and Duty Cycle function increase preciosion in sample.

SONABOZ Sound Abating Chamber

0-125-0001 Biologics each
EUR 1020
Description: Reduces cavitational sound emitted during processing.

Model 3000 Ultrasonic Homogenizer

0-127-0002 Biologics 210-240V/50-60Hz
EUR 4120
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip and includes an intergrated Sound Abating Chmaber to reduce cavitational sound emitted during processing. The Timer and Duty Cycle function increase preciosion in sample.

Model 3000MP Ultrasonic Homogenizer

0-128-0002 Biologics 210-240V/50-60Hz
EUR 4720
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip with preciosion control from a microprocessor and a graphical user interface displayed on a large (145 mm) LCD display. The integrated Sound Abating Chamber reduces cavitational sound emitted during processing.

OMNICON® Zone Reader, 210-240V/50-60Hz

0-131-0002 Biologics 210-240V/50-60Hz
EUR 35200
Description: Designed to Perform multi-plate Assays on round 90/100mm Petri Dishes. The integrated LED illumination system provides transmitted light for brightfield and darkfield illumination of transparent media.

OMNI-Noculator Peni Cylinder Filler, 210-240V/50-60Hz

0-134-0002 Biologics 210-240V/50-60Hz
EUR 32200
Description: A robotic liquid handling system designed to dispense Peni Cylinders and fill Peni Cylinders with the corresponding antibiotic liquid sample.

Peni Cylinder Dispenser with Manual Hopper

0-144-0002 Biologics each
EUR 5406
Description: Dispenser can be configured to dispense 4 or 6 Peni Cylinders onto a petri dish.

Peni Cylinder Dispenser with Motorized Hopper, 100-240V/50-60Hz

0-144-0003 Biologics 100-240V/50-60Hz
EUR 6254
Description: The motorized hopper can be configured to dispense 4 or 6 Peni Cylinders onto a petri Dispenser can be disassembled for disinfection.

Stainless Steel Peni Cylinder with Flat Face

0-144-0005 Biologics 6mm I.D. x 8mm O.D. x 10mm Long
EUR 399
Description: sold in packages of 100 pieces

Stainless Steel Peni Cylinder with Chamfered Face

0-144-0006 Biologics 6mm I.D. x 8mm O.D. x 10mm Long
EUR 412
Description: sold in packages of 100 pieces

Custom development of ELISAs for other species or antibody isotypes not listed in the catalog. Custom testing of samples for IgG/IgM/IgA or total (IgG+IgM+IgA)

000-CUS Alpha Diagnostics Custom
EUR 602

Alpha-Bungarotoxin, CF®405S, 500 ug

00002 Biotium 1UG
EUR 527
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-bungarotoxin, CF405s

00002 Cusabio 500uG
EUR 594
Description: Minimum order quantity: 1 unit of 500uG

Alpha-Bungarotoxin, CF®405S, 500 ug

00002-1 Biotium EA
EUR 527

Alpha-Bungarotoxin, CF®405S 100ug

00002-100ug Biotium 100uG
EUR 132
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®680R, 500 ug

9-00003 Biotium
  • Ask for price
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  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®680R, 500 ug

00003-1 Biotium EA
EUR 527

Alpha-Bungarotoxin, CF®680R 100ug

9-00003 Biotium
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  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®640R, 500 ug

9-00004 Biotium
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  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®640R, 500 ug

00004-1 Biotium EA
EUR 527

Alpha-Bungarotoxin, CF®640R 100ug

9-00004 Biotium
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®488A, 500 ug

9-00005 Biotium
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®488A, 500 ug

00005-1 Biotium EA
EUR 527

Alpha-Bungarotoxin CF®488A 100ug

9-00005 Biotium
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®568, 500 ug

9-00006 Biotium
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®568, 500 ug

00006-1 Biotium EA
EUR 527

Alpha-Bungarotoxin, CF®568 100ug

9-00006 Biotium
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®594, 500 ug

9-00007 Biotium
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®594, 500 ug

00007-1 Biotium EA
EUR 527

Alpha-Bungarotoxin CF®594 100ug

9-00007 Biotium
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®633, 500 ug

9-00009 Biotium
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®633, 500 ug

00009-1 Biotium EA
EUR 527

Alpha-Bungarotoxin, CF®633 100ug

9-00009 Biotium
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

SARS-CoV-2 Indicator Cell Line for RNA Replication - GFP Reporter only

0001-PP-001 IBT Bioservices 1 cell line (can order x amount)
EUR 12000
Description: SARS-CoV-2 GFP reporter cell line using HEK293T (ACE2/TMPRSS2) cells

Alpha-Bungarotoxin, 1 mg

00010-1 Biotium 1MG
EUR 193
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, 1 mg

00010-1-1 Biotium EA
EUR 193

Fluorescein-Alpha-Bungarotoxin, 500 ug

00011 Biotium 500uG
EUR 376
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Fluorescein-Alpha-Bungarotoxin, 500 ug

00011-1 Biotium EA
EUR 376

Tetramethylrhodamine-Alpha-Bungarotoxin, 500 ug

00012 Biotium 500uG
EUR 394
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Tetramethylrhodamine-Alpha-Bungarotoxin, 500 ug

00012-1 Biotium EA
EUR 394

Fluorescein-alpha-bungarotoxin, 10x50ug

00013 Biotium 10ST
EUR 436
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Fluorescein-alpha-bungarotoxin, 10x50ug

00013-1 Biotium EA
EUR 436

Tetramethylrhodamine-A-Bungarotoxin, 10x50 ug

00014 Biotium 10ST
EUR 494
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Tetramethylrhodamine-A-Bungarotoxin, 10x50 ug

00014-1 Biotium EA
EUR 494

Sulforhodamine 101-Alpha-Bungarotoxin, 500 ug

00015 Biotium 500uG
EUR 494
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Sulforhodamine 101-Alpha-Bungarotoxin, 500 ug

00015-1 Biotium EA
EUR 494

Sulforhodamine 101-Alpha-Bungarotoxin, 50 ug

00016 Biotium 10ST
EUR 560
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Sulforhodamine 101-Alpha-Bungarotoxin, 50 ug

00016-1 Biotium EA
EUR 560

Biotin-XX-A-Bungarotoxin, 500 ug

00017 Biotium 500uG
EUR 455
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Biotin-XX-A-Bungarotoxin, 500 ug

00017-1 Biotium EA
EUR 455

Alpha-Bungarotoxin, CF®555, 500 ug

9-00018 Biotium
  • Ask for price
  • Ask for price
  • 500uG
  • 100ug
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®555, 500 ug

00018-1 Biotium EA
EUR 527

Alpha-Bungarotoxin, CF®555 100ug

9-00018 Biotium
  • Ask for price
  • Ask for price
  • 500uG
  • 100ug
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Acrylamide, Chemzymes Ultra Pure®

00019-100 Polysciences Europe GmbH 100g
EUR 101.52
Description: 79-06-1

Acrylamide, Chemzymes Ultra Pure®

00019-500 Polysciences Europe GmbH 500g
EUR 270
Description: 79-06-1

Biotin-cAMP, 1 mg

00020 Biotium 1MG
EUR 298
Description: N/A

Biotin-cAMP, 1 mg

00020-1 Biotium 20ST
EUR 298
Description: N/A

Biotin-cAMP, 50 ug

00020-1-1 Biotium EA
EUR 414

Biotin-cGMP, 1 mg

00021 Biotium 1MG
EUR 331
Description: N/A

Biotin-cGMP, 1 mg

00021-1 Biotium 20ST
EUR 331
Description: N/A

Biotin-cGMP, 20x50 ug

00021-1-1 Biotium EA
EUR 447

Cyanine 644-cAMP, 1 mg

00022 Biotium 1MG
EUR 496
Description: N/A

Cyanine 644-cAMP, 1 mg

00022-1 Biotium 20ST
EUR 496
Description: N/A

Cyanine 644-cAMP, 20x50 ug

00022-1-1 Biotium EA
EUR 647

Fluorescein Methotrexate, Triammonium Salt, 1 mg

00023 Biotium 1MG
EUR 285
Description: N/A

Fluorescein Methotrexate, Triammonium Salt, 1 mg

00023-1 Biotium EA
EUR 285

Staurosporine

00025 Biotium 100uG
EUR 100
Description: N/A

Staurosporine

00025-1 Biotium EA
EUR 100

Alpha-Bungarotoxin, CF®543, 500 ug

00026 Biotium 500uG
EUR 527
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®543, 500 ug

00026-1 Biotium EA
EUR 527

Alpha-Bungarotoxin, CF®543, 100 ug

00026-100ug Biotium 1UG
EUR 132
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Rhodamine Phalloidin 300U

00027 Biotium 300
EUR 364
Description: N/A

Rhodamine Phalloidin 300U

00027-1 Biotium EA
EUR 364

Biotin-XX-Phalloidin

00028 Biotium 100U
EUR 466
Description: N/A

Biotin-XX-Phalloidin

00028-1 Biotium EA
EUR 466

Fluorescein-Phalloidin

00030 Biotium 300U
EUR 364
Description: N/A

Fluorescein-Phalloidin

00030-1 Biotium EA
EUR 364

Rhodamine 110 Phalloidin

00032 Biotium 300ST
EUR 364
Description: N/A

Rhodamine 110 Phalloidin

00032-1 Biotium EA
EUR 364

Sulforhodamine 101 (Texas Red®) Phalloidin

00033 Biotium 300EU
EUR 364
Description: N/A

Sulforhodamine 101 (Texas Red®) Phalloidin

00033-1 Biotium EA
EUR 364

Phalloidin, CF®405M

00034 Biotium 300U
EUR 482
Description: N/A

Phalloidin, CF®405M

00034-1 Biotium EA
EUR 482

Phalloidin, CF®405M

00034-T Biotium 50U
EUR 101
Description: N/A

Phalloidin, CF®405M

00034-T-1 Biotium EA
EUR 101

CF®488A-cAMP

00036 Biotium 100ug
EUR 136
Description: N/A

CF®488A-cAMP

00036-1 Biotium EA
EUR 136

CF®640R-cAMP

00037 Biotium 100ug
EUR 136
Description: N/A

CF®640R-cAMP

00037-1 Biotium EA
EUR 136

Phalloidin, CF555

00040 Biotium 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF555

00040-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF®647, 300 U

00041 Biotium 300U
EUR 482
Description: N/A

Phalloidin, CF®647, 300 U

00041-1 Biotium EA
EUR 482

Phalloidin, CF®647, 50 U

00041-T Biotium 50U
EUR 101
Description: N/A

Phalloidin, CF®647, 50 U

00041-T-1 Biotium EA
EUR 101

Phalloidin, CF®488A, 300 U

00042 Biotium 300U
EUR 482
Description: N/A

Phalloidin, CF®488A, 300 U

00042-1 Biotium EA
EUR 482

Phalloidin, CF®488A, 50 U

00042-T Biotium 50U
EUR 101
Description: N/A

Phalloidin, CF®488A, 50 U

00042-T-1 Biotium EA
EUR 101

Phalloidin, CF®543, 300 U

00043 Biotium 300U
EUR 482
Description: N/A

Phalloidin, CF®543, 300 U

00043-1 Biotium EA
EUR 482

Phalloidin, CF®543, 50 U

00043-T Biotium 50U
EUR 101
Description: N/A

Phalloidin, CF®543, 50 U

00043-T-1 Biotium EA
EUR 101

Phalloidin, CF®568, 300 U

00044 Biotium 300U
EUR 482
Description: N/A

Phalloidin, CF®568, 300 U

00044-1 Biotium EA
EUR 482

Phalloidin, CF®568, 50 U

00044-T Biotium 50U
EUR 101
Description: N/A

Phalloidin, CF®568, 50 U

00044-T-1 Biotium EA
EUR 101

Phalloidin, CF®594, 300 U

00045 Biotium 300U
EUR 482
Description: N/A

Phalloidin, CF®594, 300 U

00045-1 Biotium EA
EUR 482

Phalloidin, CF®594, 50 U

00045-T Biotium 50U
EUR 101
Description: N/A

Phalloidin, CF®594, 50 U

00045-T-1 Biotium EA
EUR 101

Phalloidin, CF®633, 300 U

00046 Biotium 300U
EUR 482
Description: N/A

Phalloidin, CF®633, 300 U

00046-1 Biotium EA
EUR 482

Phalloidin, CF®633, 50 U

00046-T Biotium 50U
EUR 101
Description: N/A

Phalloidin, CF®633, 50 U

00046-T-1 Biotium EA
EUR 101

Phalloidin, CF®660R, 300 U

00047 Biotium 300U
EUR 482
Description: N/A

Phalloidin, CF®660R, 300 U

00047-1 Biotium EA
EUR 482

Phalloidin, CF®660R, 50 U

00047-T Biotium 50U
EUR 101
Description: N/A

Phalloidin, CF®660R, 50 U

00047-T-1 Biotium EA
EUR 101

Phalloidin, CF®680R, 300 U

00048 Biotium 300U
EUR 513
Description: N/A

Phalloidin, CF®680R, 300 U

00048-1 Biotium EA
EUR 513

Phalloidin, CF®680R, 50 U

00048-T Biotium 50U
EUR 101
Description: N/A

Phalloidin, CF®680R, 50 U

00048-T-1 Biotium EA
EUR 101

Phalloidin, CF®350, 300 U

00049 Biotium 300U
EUR 482
Description: N/A

Phalloidin, CF®350, 300 U

00049-1 Biotium EA
EUR 482

Phalloidin, CF®350, 50 U

00049-T Biotium 50U
EUR 101
Description: N/A

Phalloidin, CF®350, 50 U

00049-T-1 Biotium EA
EUR 101

Phalloidin, CF®640R, 300 U

00050 Biotium 300U
EUR 482
Description: N/A

Phalloidin, CF®640R, 300 U

00050-1 Biotium EA
EUR 482

Phalloidin, CF®640R, 50 U

00050-T Biotium 50U
EUR 101
Description: N/A

Phalloidin, CF®640R, 50 U

00050-T-1 Biotium EA
EUR 101

Phalloidin, CF®532, 300 U

00051 Biotium 300U
EUR 482
Description: N/A

Phalloidin, CF®532, 300 U

00051-1 Biotium EA
EUR 482
×

Amongst these, 215 DEGs had been upregulated and 242 DEGs had been downregulated within the acute injured samples in contrast with unhurt samples. The GO enrichment evaluation indicated that these DEGs had been primarily concerned in transport, the oxidation-reduction course of, the metabolic course of, steel ion binding, hydrolase exercise, and oxidoreductase exercise. The KEGG evaluation revealed that these DEGs had been considerably enriched within the PI3K-Akt signaling pathway, protein digestion and absorption pathway, and focal adhesion pathway. The hub genes together with Hnf4α, Pck1 and Timp1 had been validated by the qRT-PCR assay in NRK-49F cells within the H/R mannequin.

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